DPF2 and RUBCN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DPF2	RUBCN
Description		double PHD fingers 2	rubicon autophagy regulator
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol SWI/SNF Complex NBAF Complex	Nucleoplasm Lysosome Endosome Early Endosome Late Endosome Golgi Apparatus Cytosol
	Molecular Function	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K9me2/3 Reader Activity Histone H3K14ac Reader Activity Histone H4K16ac Reader Activity	Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity Phosphatidylinositol Phosphate Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of G0 To G1 Transition Apoptotic Signaling Pathway Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Immune System Process Endocytosis Phagocytosis Autophagy Negative Regulation Of Autophagy Negative Regulation Of Endocytosis Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Multivesicular Body Sorting Pathway Negative Regulation Of Autophagosome Maturation
Pathways		Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Mean spheric corpuscular volume ( 32888494) Urate levels ( 31578528)
Interacting Genes		21 interacting genes: FHL2 GOLGA6L9 H3-4 H3C1 H4C1 HSF2BP LDOC1 LNX1 MEOX2 NFKB2 PICK1 REL RELA RELB RINT1 RUBCN TTC23L TXNDC12 UPF2 ZNF212 ZNF655	18 interacting genes: ANKRD11 BRD1 BYSL DPF2 DRC4 ENKD1 EXOC1 FAM161A FAM9B NME7 PYCARD RNF34 SMAD9 TCEANC VEZF1 ZFYVE21 ZNF250 ZNF648
Entrez ID		5977	9711
HPRD ID		03394	11069
Ensembl ID		ENSG00000133884	ENSG00000145016
Uniprot IDs		J3KMZ8 Q92785	A0A9L9PY84 Q8N4U6 Q92622
PDB IDs		3IUF 5B79 5VDC 6LTH 6LTJ	6WCW
Enriched GO Terms of Interacting Partners?		NF-kappaB Complex Non-canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Interferon-beta Production Structural Constituent Of Chromatin Response To Muramyl Dipeptide Nucleosome Assembly Nucleosome Nucleosome Organization Nucleoplasm
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