RUBCN and EXOC1

Number of citations of the paper that reports this interaction (PubMedID 21241894)
61

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		RUBCN	EXOC1
Description		rubicon autophagy regulator	exocyst complex component 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Lysosome Endosome Early Endosome Late Endosome Golgi Apparatus Cytosol	Exocyst Cytoplasm Cytosol Plasma Membrane Membrane Perinuclear Region Of Cytoplasm Flemming Body
	Molecular Function	Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity Phosphatidylinositol Phosphate Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding
	Biological Process	Immune System Process Endocytosis Phagocytosis Autophagy Negative Regulation Of Autophagy Negative Regulation Of Endocytosis Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Multivesicular Body Sorting Pathway Negative Regulation Of Autophagosome Maturation	Mitotic Cytokinesis Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Protein Transport Regulation Of Macroautophagy Defense Response To Virus Membrane Fission Vesicle Tethering Involved In Exocytosis
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS			Cerebrospinal P-tau181p levels ( 28247064) Cervical cancer ( 23817570) Daytime sleep phenotypes ( 27126917) Urinary albumin excretion ( 32277301) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: ANKRD11 BRD1 BYSL DPF2 DRC4 ENKD1 EXOC1 FAM161A FAM9B NME7 PYCARD RNF34 SMAD9 TCEANC VEZF1 ZFYVE21 ZNF250 ZNF648	29 interacting genes: ATG14 CCDC88A CCDC93 CCSER2 CDC5L CEP295 COLEC12 DISC1 DST ITSN1 KANSL1 KDM1A LUC7L2 MACF1 MTNR1A NUF2 NUP54 RALA RB1CC1 RESF1 RUBCN SFR1 SH3BP5 SNCA SPTAN1 SRGAP2 SYBU TRAF3IP1 TRIO
Entrez ID		9711	55763
HPRD ID		11069	07615
Ensembl ID		ENSG00000145016	ENSG00000090989
Uniprot IDs		A0A9L9PY84 Q8N4U6 Q92622	Q9NV70
PDB IDs		6WCW
Enriched GO Terms of Interacting Partners?			Microtubule Binding Microtubule-based Process Cytoskeleton Organelle Organization Phosphatidylinositol 3-kinase Inhibitor Activity Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Cellular Localization Cell Leading Edge Cell Projection Cytoskeleton Organization Positive Regulation Of Cell Size Regulation Of Cytoskeleton Organization Microtubule Molecular Adaptor Activity Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Cell Projection Organization Actin Binding Cytoplasmic Vesicle Positive Regulation Of Cellular Component Organization Guanyl-nucleotide Exchange Factor Activity Intracellular Transport Regulation Of Organelle Organization Phagophore Assembly Site Membrane Establishment Of Localization In Cell Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Regulation Of Synapse Organization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Negative Regulation Of Protein-containing Complex Assembly Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Microtubule-based Process Negative Regulation Of Cellular Component Organization Phagophore Assembly Site Ribophagy Protein-membrane Adaptor Activity Extrinsic Component Of Phagophore Assembly Site Membrane Positive Regulation Of Neuroblast Proliferation Lamellipodium Assembly Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Lamellipodium Assembly Involved In Ameboidal Cell Migration Regulation Of Endocytosis Positive Regulation Of Axon Extension
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