PRPH2 and CNGB1

Number of citations of the paper that reports this interaction (PubMedID 11641407)
0

Data Source:
HPRD (in vitro)

		PRPH2	CNGB1
Description		peripherin 2	cyclic nucleotide gated channel subunit beta 1
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Plasma Membrane Membrane Cell Projection	Photoreceptor Outer Segment Plasma Membrane Membrane Intracellular Cyclic Nucleotide Activated Cation Channel Complex Golgi-associated Vesicle Membrane Cell Projection Terminal Bouton Ciliary Membrane Non-motile Cilium Membrane Rod Photoreceptor Outer Segment Transmembrane Transporter Complex
	Molecular Function	Protein Binding Protein Homodimerization Activity	Nucleotide Binding Intracellularly Cyclic Nucleotide-activated Monoatomic Cation Channel Activity Intracellularly CAMP-activated Cation Channel Activity Intracellularly CGMP-activated Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity CAMP Binding CGMP Binding Cyclic Nucleotide-activated Monoatomic Ion Channel Activity Protein-containing Complex Binding
	Biological Process	Cell Adhesion Visual Perception Response To Low Light Intensity Stimulus Photoreceptor Cell Outer Segment Organization Detection Of Light Stimulus Involved In Visual Perception Protein Homooligomerization Protein Heterooligomerization Protein Maturation Retina Development In Camera-type Eye Protein Localization To Plasma Membrane	Retina Homeostasis Monoatomic Ion Transport Monoatomic Cation Transport Potassium Ion Transport Sodium Ion Transport Calcium Ion Transport G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Sensory Perception Of Smell Positive Regulation Of Gene Expression Olfactory Nerve Maturation Protein Localization To Organelle Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Detection Of Light Stimulus Involved In Visual Perception Detection Of Chemical Stimulus Involved In Sensory Perception Of Smell Regulation Of Cytosolic Calcium Ion Concentration Membrane Depolarization Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Response To Odorant
Pathways			Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases		Vitelliform macular dystrophy, including: Best disease / Juvenile vitelliform macular dystrophy (VMD2) ; Adult-onset vitelliform macular dystrophy (AVMD) Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Retinitis pigmentosa (RP)	Retinitis pigmentosa (RP)
GWAS		Pulse pressure ( 27841878)	Initial alcohol sensitivity ( 30276832) Low density lipoprotein cholesterol levels ( 32154731) Prudent dietary pattern ( 28644415) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Triglyceride levels ( 32154731)
Interacting Genes		4 interacting genes: CNGB1 GRAP2 PRPH ROM1	3 interacting genes: ABCA4 PNN PRPH2
Entrez ID		5961	1258
HPRD ID		01553	07204
Ensembl ID		ENSG00000112619	ENSG00000070729
Uniprot IDs		P23942	Q14028
PDB IDs		7ZW1	7RH9 7RHG 7RHH 7RHI 7RHJ 7RHK 7RHL 8DGH 8DGK
Enriched GO Terms of Interacting Partners?		Photoreceptor Cell Outer Segment Organization Detection Of Light Stimulus Involved In Visual Perception Detection Of Light Stimulus Photoreceptor Outer Segment Cyclic Nucleotide-activated Monoatomic Ion Channel Activity Olfactory Nerve Maturation Detection Of Abiotic Stimulus Non-motile Cilium Membrane Detection Of Stimulus Involved In Sensory Perception Nerve Maturation Visual Perception Response To Odorant Sensory Perception Of Light Stimulus Type III Intermediate Filament Detection Of Stimulus Cell Projection Intracellularly CGMP-activated Cation Channel Activity Intracellular Cyclic Nucleotide Activated Cation Channel Complex Intracellularly Cyclic Nucleotide-activated Monoatomic Cation Channel Activity Protein Localization To Photoreceptor Outer Segment Intracellularly CAMP-activated Cation Channel Activity Response To Light Stimulus Rod Photoreceptor Outer Segment Protein Localization To Non-motile Cilium Photoreceptor Outer Segment Membrane Transmembrane Transporter Complex Retina Morphogenesis In Camera-type Eye CGMP Binding Golgi-associated Vesicle Membrane Camera-type Eye Photoreceptor Cell Differentiation Retina Vasculature Development In Camera-type Eye Response To Radiation Retina Homeostasis Eye Photoreceptor Cell Differentiation Sensory Perception CAMP Binding Plasma Membrane Photoreceptor Cell Differentiation Protein Heterooligomerization Ligand-gated Monoatomic Ion Channel Activity Protein Localization To Organelle Sodium Channel Activity Terminal Bouton Photoreceptor Cell Maintenance Phototransduction Phosphotyrosine Residue Binding Detection Of Chemical Stimulus Involved In Sensory Perception Of Smell Membrane Depolarization Ciliary Membrane Regulation Of Cytosolic Calcium Ion Concentration	N-retinylidene-phosphatidylethanolamine Flippase Activity Rod Photoreceptor Disc Membrane Flippase Activity Detection Of Light Stimulus Detection Of Abiotic Stimulus Photoreceptor Outer Segment Response To Low Light Intensity Stimulus Retinol Transmembrane Transporter Activity Visual Perception Phosphatidylethanolamine Flippase Activity Sensory Perception Of Light Stimulus Phospholipid Transfer To Membrane Retinol Transport Detection Of Stimulus All-trans Retinal Binding Terpenoid Transport 11-cis Retinal Binding Response To Light Stimulus Retinoid Binding Response To Radiation ATPase-coupled Intramembrane Lipid Transporter Activity Sensory Perception Phototransduction, Visible Light Photoreceptor Cell Outer Segment Organization Response To Light Intensity Phospholipid Transporter Activity Retinal Metabolic Process Photoreceptor Disc Membrane Exon-exon Junction Complex Detection Of Light Stimulus Involved In Visual Perception Detection Of Visible Light Protein Heterooligomerization Desmosome ATPase-coupled Transmembrane Transporter Activity Phospholipid Translocation Photoreceptor Cell Maintenance ABC-type Transporter Activity Phototransduction Lipid Translocation Cell Adhesion Nervous System Process Regulation Of Membrane Lipid Distribution Photoreceptor Inner Segment Aldehyde Metabolic Process Retinoid Metabolic Process Diterpenoid Metabolic Process Retina Development In Camera-type Eye Phospholipid Transport Cell Projection Catalytic Step 2 Spliceosome
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