CNGB1

Description		cyclic nucleotide gated channel subunit beta 1
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Plasma Membrane Membrane Intracellular Cyclic Nucleotide Activated Cation Channel Complex Golgi-associated Vesicle Membrane Cell Projection Terminal Bouton Ciliary Membrane Non-motile Cilium Membrane Rod Photoreceptor Outer Segment Transmembrane Transporter Complex
	Molecular Function	Nucleotide Binding Intracellularly Cyclic Nucleotide-activated Monoatomic Cation Channel Activity Intracellularly CAMP-activated Cation Channel Activity Intracellularly CGMP-activated Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity CAMP Binding CGMP Binding Cyclic Nucleotide-activated Monoatomic Ion Channel Activity Protein-containing Complex Binding
	Biological Process	Retina Homeostasis Monoatomic Ion Transport Monoatomic Cation Transport Potassium Ion Transport Sodium Ion Transport Calcium Ion Transport G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Sensory Perception Of Smell Positive Regulation Of Gene Expression Olfactory Nerve Maturation Protein Localization To Organelle Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Detection Of Light Stimulus Involved In Visual Perception Detection Of Chemical Stimulus Involved In Sensory Perception Of Smell Regulation Of Cytosolic Calcium Ion Concentration Membrane Depolarization Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Response To Odorant
Pathways		Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases		Retinitis pigmentosa (RP)
GWAS		Initial alcohol sensitivity ( 30276832) Low density lipoprotein cholesterol levels ( 32154731) Prudent dietary pattern ( 28644415) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Triglyceride levels ( 32154731)
Novel Interacting Genes		3 novel interacting genes: ABCA4 PNN PRPH2
Interacting Genes		3 interacting genes: ABCA4 PNN PRPH2
Entrez ID		1258
HPRD ID		07204
Ensembl ID		ENSG00000070729
Uniprot IDs		Q14028
PDB IDs		7RH9 7RHG 7RHH 7RHI 7RHJ 7RHK 7RHL 8DGH 8DGK
Enriched GO Terms of Interacting Partners?		N-retinylidene-phosphatidylethanolamine Flippase Activity Rod Photoreceptor Disc Membrane Flippase Activity Detection Of Light Stimulus Detection Of Abiotic Stimulus Photoreceptor Outer Segment Response To Low Light Intensity Stimulus Retinol Transmembrane Transporter Activity Visual Perception Phosphatidylethanolamine Flippase Activity Sensory Perception Of Light Stimulus Phospholipid Transfer To Membrane Retinol Transport Detection Of Stimulus All-trans Retinal Binding Terpenoid Transport 11-cis Retinal Binding Response To Light Stimulus Retinoid Binding Response To Radiation ATPase-coupled Intramembrane Lipid Transporter Activity Sensory Perception Phototransduction, Visible Light Photoreceptor Cell Outer Segment Organization Response To Light Intensity Phospholipid Transporter Activity Retinal Metabolic Process Photoreceptor Disc Membrane Exon-exon Junction Complex Detection Of Light Stimulus Involved In Visual Perception Detection Of Visible Light Protein Heterooligomerization Desmosome ATPase-coupled Transmembrane Transporter Activity Phospholipid Translocation Photoreceptor Cell Maintenance ABC-type Transporter Activity Phototransduction Lipid Translocation Cell Adhesion Nervous System Process Regulation Of Membrane Lipid Distribution Photoreceptor Inner Segment Aldehyde Metabolic Process Retinoid Metabolic Process Diterpenoid Metabolic Process Retina Development In Camera-type Eye Phospholipid Transport Cell Projection Catalytic Step 2 Spliceosome
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