NTN4 and DUSP6

		NTN4	DUSP6
Description		netrin 4	dual specificity phosphatase 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Plasma Membrane Laminin Complex	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Laminin-1 Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity
	Biological Process	Axon Guidance Animal Organ Morphogenesis Tissue Development Neuron Remodeling Cell Migration Substrate Adhesion-dependent Cell Spreading Regulation Of Branching Involved In Salivary Gland Morphogenesis By Extracellular Matrix-epithelial Cell Signaling Basement Membrane Assembly	MAPK Cascade Signal Transduction Response To Xenobiotic Stimulus Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Response To Nitrosative Stress Regulation Of Heart Growth ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor
Pathways		Non-integrin membrane-ECM interactions Netrin-1 signaling	RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Allergic dermatitis (nickel) ( 23921680) Blood protein levels ( 30072576) BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 23535729 23535733 29059683) Breast size ( 27182965) Diastolic blood pressure ( 30224653) Diffusing capacity of carbon monoxide ( 30694715) Refractive error ( 32231278)	Age at first sexual intercourse ( 34211149) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 29325848 30478444) Night sleep phenotypes ( 27126917)
Interacting Genes		14 interacting genes: ADAMTSL4 CASK CYSRT1 DUSP6 HOXA1 KPRP KRTAP10-8 KRTAP21-2 KRTAP5-9 LCE1C MEOX2 NBPF19 NOTCH2NLA PLSCR1	20 interacting genes: AATK CHRNE ERBB4 GABRA5 GLA IGF1 LMTK2 LTK MAPK1 MAPK3 MDFI NFYB NTN4 ROR2 SRPK1 TEX11 TPO TTN TXK ZNF212
Entrez ID		59277	1848
HPRD ID		10121	04124
Ensembl ID		ENSG00000074527	ENSG00000139318
Uniprot IDs		A8K3H6 B2RE43 Q9HB63	Q16828 Q53GP9
PDB IDs			1HZM 1MKP
Enriched GO Terms of Interacting Partners?		Epidermis Development Tissue Development Intermediate Filament Establishment Of Skin Barrier Skin Epidermis Development Semicircular Canal Formation Epithelium Development Pigment Cell Development	Protein Kinase Activity Kinase Activity Protein Tyrosine Kinase Activity Protein Phosphorylation Phosphorylation Protein Autophosphorylation ATP Binding ERBB2 Signaling Pathway Protein Serine Kinase Activity Interleukin-34-mediated Signaling Pathway Protein Serine/threonine Kinase Activity Nucleotide Binding Transferase Activity Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Golgi Inheritance Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neuroinflammatory Response Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Peptidyl-tyrosine Autophosphorylation Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Bergmann Glial Cell Differentiation Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Insulin Receptor Signaling Pathway Cellular Developmental Process MAP Kinase Activity GABA Receptor Binding Regulation Of Golgi Organization Pseudopodium Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Positive Regulation Of Macrophage Chemotaxis Gland Development Glial Cell Differentiation Positive Regulation Of Neuroinflammatory Response Animal Organ Formation Face Development Peptidyl-threonine Phosphorylation Stress-activated MAPK Cascade Cell Development
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