DUSP6 and CHRNE

		DUSP6	CHRNE
Description		dual specificity phosphatase 6	cholinergic receptor nicotinic epsilon subunit
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Plasma Membrane Acetylcholine-gated Channel Complex Membrane Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Monoatomic Cation Transmembrane Transporter Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	MAPK Cascade Signal Transduction Response To Xenobiotic Stimulus Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Response To Nitrosative Stress Regulation Of Heart Growth ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor	Skeletal Muscle Contraction Monoatomic Ion Transport Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Membrane Depolarization Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Acetylcholine Receptor Signaling Pathway Monoatomic Cation Transmembrane Transport
Pathways		RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
Drugs
Diseases			Congenital myasthenic syndrome
GWAS		Age at first sexual intercourse ( 34211149) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 29325848 30478444) Night sleep phenotypes ( 27126917)	Alzheimer's disease ( 34099642) Keratoconus ( 33649486) Platelet count ( 29403010)
Interacting Genes		20 interacting genes: AATK CHRNE ERBB4 GABRA5 GLA IGF1 LMTK2 LTK MAPK1 MAPK3 MDFI NFYB NTN4 ROR2 SRPK1 TEX11 TPO TTN TXK ZNF212	2 interacting genes: CHRNA1 DUSP6
Entrez ID		1848	1145
HPRD ID		04124	00008
Ensembl ID		ENSG00000139318	ENSG00000108556
Uniprot IDs		Q16828 Q53GP9	Q04844
PDB IDs		1HZM 1MKP
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Protein Tyrosine Kinase Activity Protein Phosphorylation Phosphorylation Protein Autophosphorylation ATP Binding ERBB2 Signaling Pathway Protein Serine Kinase Activity Interleukin-34-mediated Signaling Pathway Protein Serine/threonine Kinase Activity Nucleotide Binding Transferase Activity Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Golgi Inheritance Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neuroinflammatory Response Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Peptidyl-tyrosine Autophosphorylation Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Bergmann Glial Cell Differentiation Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Insulin Receptor Signaling Pathway Cellular Developmental Process MAP Kinase Activity GABA Receptor Binding Regulation Of Golgi Organization Pseudopodium Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Positive Regulation Of Macrophage Chemotaxis Gland Development Glial Cell Differentiation Positive Regulation Of Neuroinflammatory Response Animal Organ Formation Face Development Peptidyl-threonine Phosphorylation Stress-activated MAPK Cascade Cell Development	Acetylcholine Binding Acetylcholine Receptor Activity Skeletal Muscle Tissue Growth Musculoskeletal Movement Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine-gated Channel Complex Response To Nitrosative Stress MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Synaptic Transmission, Cholinergic Muscle Cell Cellular Homeostasis Neuromuscular Junction Development Extracellular Ligand-gated Monoatomic Ion Channel Activity Presynaptic Modulation Of Chemical Synaptic Transmission Skeletal Muscle Contraction Neuronal Action Potential Neuromuscular Synaptic Transmission Postsynaptic Specialization Membrane Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Response To Nicotine Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Membrane Depolarization ERK1 And ERK2 Cascade Excitatory Postsynaptic Potential Neuron Cellular Homeostasis Regulation Of Heart Growth Negative Regulation Of ERK1 And ERK2 Cascade Neuromuscular Junction Striated Muscle Contraction Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Regulation Of Organ Growth Protein Tyrosine Phosphatase Activity Regulation Of Postsynaptic Membrane Potential Action Potential Neuromuscular Process
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