RHOU and JAM3

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		RHOU	JAM3
Description		ras homolog family member U	junctional adhesion molecule 3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Microvillus Cell-cell Junction Bicellular Tight Junction Membrane Desmosome Filamentous Actin Paranodal Junction Schmidt-Lanterman Incisure Cell-cell Contact Zone Tight Junction Anchoring Junction Protein Complex Involved In Cell Adhesion
	Molecular Function	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Integrin Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Cell-cell Adhesion Mediator Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion	Angiogenesis Neutrophil Homeostasis Adaptive Immune Response Myeloid Progenitor Cell Differentiation Leukocyte Migration Involved In Inflammatory Response Cell Adhesion Cell-matrix Adhesion Spermatogenesis Spermatid Development Cell Migration Transmission Of Nerve Impulse Establishment Of Cell Polarity Cell Differentiation Negative Regulation Of Integrin Activation Negative Regulation Of Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Adherens Junction Assembly Protein Localization To Cell Surface Maintenance Of Blood-brain Barrier Myelination Apical Protein Localization System Development Leukocyte Migration Regulation Of Neutrophil Chemotaxis Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Hematopoietic Stem Cell Migration To Bone Marrow Granulocyte Migration Cell-cell Adhesion Protein Localization To Cell Junction Positive Regulation Of Membrane Permeability Positive Regulation Of Monocyte Extravasation
Pathways		Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle	Cell surface interactions at the vascular wall Integrin cell surface interactions
Drugs
Diseases
GWAS		Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)	Blood protein levels ( 30072576) Neutrophil count ( 32888494)
Interacting Genes		126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84	8 interacting genes: F2RL2 ITGAM ITGAX JAM2 MEOX2 PICK1 RHOU TJP1
Entrez ID		58480	83700
HPRD ID		06965	06042
Ensembl ID		ENSG00000116574	ENSG00000166086
Uniprot IDs		Q7L0Q8	Q9BX67
PDB IDs		2Q3H
Enriched GO Terms of Interacting Partners?		Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin	Regulation Of Establishment Of Protein Localization Cell-cell Adhesion Integrin Binding Integrin Complex Heterotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Tight Junction Podosome Regulation Of Myelination Positive Regulation Of Establishment Of Protein Localization Cell Adhesion Tertiary Granule Membrane Regulation Of Protein Localization Cellular Component Maintenance Plasma Membrane Regulation Of Cell Migration Anchoring Junction Proteinase-activated Receptor Activity Integrin AlphaM-beta2 Complex Integrin-mediated Signaling Pathway Regulation Of Cell Motility Integrin AlphaX-beta2 Complex Regulation Of Locomotion Positive Regulation Of Endothelial Tube Morphogenesis Cell-matrix Adhesion Regulation Of Secretion By Cell Thrombin-activated Receptor Activity Regulation Of Secretion Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Neutrophil Degranulation Response To Curcumin Complement-mediated Synapse Pruning Negative Regulation Of Catecholamine Metabolic Process Vertebrate Eye-specific Patterning Cell-substrate Adhesion Ectodermal Cell Differentiation Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Regulation Of Nervous System Process Positive Regulation Of Cell Motility Somite Specification Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Adherens Junction Bicellular Tight Junction Membrane Curvature Sensor Activity Hematopoietic Stem Cell Migration To Bone Marrow Protein Complex Involved In Cell Adhesion
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