PVR and CD96

Number of citations of the paper that reports this interaction (PubMedID 19056733)
0

Data Source:
HPRD (in vitro)

		PVR	CD96
Description		PVR cell adhesion molecule	CD96 molecule
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Membrane	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Virus Receptor Activity Protein Binding Signaling Receptor Activity Receptor Ligand Activity Cell Adhesion Molecule Binding Cell Adhesion Mediator Activity
	Biological Process	Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Natural Killer Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell Susceptibility To T Cell Mediated Cytotoxicity	Negative Regulation Of Natural Killer Cell Cytokine Production Inflammatory Response Immune Response Cell Adhesion Cell-matrix Adhesion Response To Lipopolysaccharide Negative Regulation Of Type II Interferon Production
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Nectin/Necl trans heterodimerization	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Sphingosine Myristic acid
Diseases			C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
GWAS		Alzheimer's disease ( 24755620) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Mean platelet volume ( 27863252 32888494) Multiple sclerosis ( 21833088) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Platelet distribution width ( 32888494)	Anti-adalimumab antibody production in response to treatment in Crohn's disease ( 31043678) Current cigarettes per day in chronic obstructive pulmonary disease ( 21685187)
Interacting Genes		76 interacting genes: ADIPOQ ANKRD46 AP1M2 AQP10 BRICD5 C3orf52 CD226 CD47 CD96 CLDN19 CTXN3 CYB561A3 CYSRT1 DMPK DYNLT1 DYNLT3 EBP EDDM3B GMEB2 GPRC5D HHATL HOXA1 INSIG2 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-1 KRTAP3-3 KRTAP6-3 KRTAP9-3 MFSD11 NBPF19 NECTIN1 NECTIN2 NECTIN3 NINJ1 NINJ2 NOTCH2NLA OLFM4 PGA4 PLA2G3 PLAT PLP2 PLPP6 PSG11 PSG9 PSMD8 RUSF1 SCD SLC22A4 SLC30A2 SLC35B4 SLC41A2 SMIM1 SNAP47 SYS1 TAS2R19 TIGIT TM6SF2 TMBIM6 TMEM147 TMEM229B TMEM54 TMEM65 TMEM79 TSPO VAMP5 VTN WNK1 ZDHHC15 ZDHHC22 ZFPL1 ZFTRAF1	1 interacting genes: PVR
Entrez ID		5817	10225
HPRD ID		01434	06916
Ensembl ID		ENSG00000073008	ENSG00000153283
Uniprot IDs		A0A0A0MSA9 A0A0C4DG49 A8K4I1 P15151	E9PEJ1 P40200 Q8WUE2
PDB IDs		1DGI 1NN8 3EPC 3EPD 3EPF 3J8F 3J9F 3UDW 3URO 4FQP 6ARQ 6ISC 6O3O	6ARQ
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Apical Junction Complex Membrane Cell Adhesion Mediator Activity Establishment Of Protein Localization To Membrane Identical Protein Binding Membrane Destabilizing Activity Regulation Of Natural Killer Cell Mediated Immunity Cell-cell Contact Zone Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cochlea Morphogenesis Regeneration Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Protein Binding Cell Adhesion Positive Regulation Of Mast Cell Activation Steroid Biosynthetic Process Cholesterol Biosynthetic Process	Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Cell Adhesion Mediator Activity Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Immune Response To Tumor Cell Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Leukocyte Mediated Cytotoxicity Virus Receptor Activity Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Cell Adhesion Molecule Binding Regulation Of T Cell Mediated Immunity Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Receptor Ligand Activity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Symbiont Entry Into Host Cell Positive Regulation Of Lymphocyte Mediated Immunity Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Leukocyte Mediated Immunity Biological Process Involved In Interaction With Host Adherens Junction Cell Killing Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Positive Regulation Of Immune Effector Process Signaling Receptor Activity Negative Regulation Of Defense Response Positive Regulation Of Innate Immune Response Immune Effector Process Focal Adhesion Regulation Of Innate Immune Response Positive Regulation Of Defense Response
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