NGB and HLCS

		NGB	HLCS
Description		neuroglobin	holocarboxylase synthetase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	GDP-dissociation Inhibitor Activity Oxygen Carrier Activity Protein Binding Oxidoreductase Activity Oxygen Binding Heme Binding Metal Ion Binding Nitrite Reductase Activity	Nucleotide Binding Catalytic Activity Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Enzyme Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Oxygen Transport Cellular Response To Hypoxia	Biotin Metabolic Process Post-translational Protein Modification Response To Biotin
Pathways		Intracellular oxygen transport	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs			Biotin
Diseases			Holocarboxylase synthetase deficiency
GWAS			Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)
Interacting Genes		24 interacting genes: AKT1 ATP1B2 BTBD2 C1orf94 DDIT4L FLOT1 GATAD2B GNAI1 GNAI2 GNAI3 GNAO1 HLCS IHO1 L3MBTL3 MAPK14 MEI4 NIF3L1 OTOS PTEN REL TDO2 TEPSIN VAC14 ZNF655	19 interacting genes: ACACB ANKRD29 BACH1 DDX52 IFNAR2 IFNGR2 IFT20 KRTAP5-9 LANCL2 MED19 NGB POT1 QKI SARS2 SNX27 SOD1 TGM3 TXNDC15 WIPF1
Entrez ID		58157	3141
HPRD ID		05602	08360
Ensembl ID		ENSG00000165553	ENSG00000159267
Uniprot IDs		A0M8W9 Q9NPG2	A0A8C8QSB1 P50747
PDB IDs		1OJ6 4MPM 7VQG 8GRZ 8WUB
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase Regulator Activity Meiotic DNA Double-strand Break Formation Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Receptor Binding Regulation Of Transport Myelin Maintenance Positive Regulation Of Myoblast Fusion Regulation Of Organ Growth Negative Regulation Of Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Regulation Of Myoblast Fusion G Protein-coupled Serotonin Receptor Signaling Pathway Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Peptidyl-serine Phosphorylation Osteoblast Differentiation Response To Prostaglandin E Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Vascular Endothelial Growth Factor Stimulus Ciliary Basal Body Regulation Of Cholesterol Biosynthetic Process Centriolar Satellite Homologous Chromosome Pairing At Meiosis Positive Regulation Of Sodium Ion Transport GTPase Activity Positive Regulation Of D-glucose Import Regulation Of Smooth Muscle Cell Proliferation Regulation Of TRNA Methylation Positive Regulation Of Steroid Biosynthetic Process Lipopolysaccharide-mediated Signaling Pathway Neuronal-glial Interaction Involved In Hindbrain Glial-mediated Radial Cell Migration Negative Regulation Of Secretion By Cell Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Negative Regulation Of Synaptic Vesicle Clustering L-tryptophan Catabolic Process To Acetyl-CoA PAS Complex Coated Vesicle Membrane Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Insulin Secretion GTP Binding Positive Regulation Of Steroid Metabolic Process
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