PTS and FNDC5

Number of citations of the paper that reports this interaction (PubMedID 11591653)
29

Data Source:
HPRD (two hybrid, in vivo)

		PTS	FNDC5
Description		6-pyruvoyltetrahydropterin synthase	fibronectin type III domain containing 5
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Extracellular Region Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Plasma Membrane Membrane
	Molecular Function	6-pyruvoyltetrahydropterin Synthase Activity Protein Binding Lyase Activity Identical Protein Binding Metal Ion Binding	Hormone Activity
	Biological Process	Amino Acid Metabolic Process Tetrahydrobiopterin Biosynthetic Process Central Nervous System Development Tetrahydrobiopterin Metabolic Process	Signal Transduction Response To Muscle Activity Positive Regulation Of Brown Fat Cell Differentiation
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs		Mycophenolate mofetil Biopterin
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Heel bone mineral density ( 30598549) Objective response to lithium treatment ( 26503763)	Daytime nap ( 33568662)
Interacting Genes		13 interacting genes: AP2M1 ATM COIL DDIT4L DDX10 FNDC5 FXR2 LNX1 NTAQ1 PBRM1 PRKG2 SDCBP THAP10	2 interacting genes: PTS TRPC3
Entrez ID		5805	252995
HPRD ID		11840	17009
Ensembl ID		ENSG00000150787	ENSG00000160097
Uniprot IDs		Q03393	A0A0A0MRR6 Q8NAU1
PDB IDs		3I2B	4LSD
Enriched GO Terms of Interacting Partners?			6-pyruvoyltetrahydropterin Synthase Activity Tetrahydrobiopterin Metabolic Process Pteridine-containing Compound Biosynthetic Process Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of Calcium Ion Transport Into Cytosol Inositol 1,4,5 Trisphosphate Binding Cation Channel Complex Calcium-activated Cation Channel Activity Store-operated Calcium Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Diol Metabolic Process Pteridine-containing Compound Metabolic Process Response To ATP Positive Regulation Of Cardiac Muscle Hypertrophy Phototransduction Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transmembrane Transport Detection Of Light Stimulus Regulation Of Cardiac Muscle Hypertrophy Calcium Channel Activity Single Fertilization Positive Regulation Of Calcium Ion Transport Detection Of Abiotic Stimulus Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport
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