FNDC5 and TRPC3

Number of citations of the paper that reports this interaction (PubMedID 35501783)
59

Data Source:
BioGRID (pull down, affinity chromatography technology)

		FNDC5	TRPC3
Description		fibronectin type III domain containing 5	transient receptor potential cation channel subfamily C member 3
Image
GO Annotations	Cellular Component	Extracellular Region Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Plasma Membrane Membrane	Plasma Membrane Membrane Cation Channel Complex
	Molecular Function	Hormone Activity	Monoatomic Ion Channel Activity Calcium-activated Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Signal Transduction Response To Muscle Activity Positive Regulation Of Brown Fat Cell Differentiation	Monoatomic Ion Transport Calcium Ion Transport Single Fertilization Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Response To ATP Monoatomic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways			Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling MECP2 regulates neuronal receptors and channels
Drugs
Diseases
GWAS		Daytime nap ( 33568662)	Asthma ( 31959851 34103634) Celiac disease and Rheumatoid arthritis ( 26546613) Emphysema imaging phenotypes ( 26030696) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307)
Interacting Genes		2 interacting genes: PTS TRPC3	22 interacting genes: BBS7 CALM1 FKBP1A FNDC5 GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2
Entrez ID		252995	7222
HPRD ID		17009	15999
Ensembl ID		ENSG00000160097	ENSG00000138741
Uniprot IDs		A0A0A0MRR6 Q8NAU1	Q13507
PDB IDs		4LSD	5ZBG 6CUD 6D7L 6DJS 7DXB 7DXC 7DXD 7DXE
Enriched GO Terms of Interacting Partners?		6-pyruvoyltetrahydropterin Synthase Activity Tetrahydrobiopterin Metabolic Process Pteridine-containing Compound Biosynthetic Process Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of Calcium Ion Transport Into Cytosol Inositol 1,4,5 Trisphosphate Binding Cation Channel Complex Calcium-activated Cation Channel Activity Store-operated Calcium Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Diol Metabolic Process Pteridine-containing Compound Metabolic Process Response To ATP Positive Regulation Of Cardiac Muscle Hypertrophy Phototransduction Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transmembrane Transport Detection Of Light Stimulus Regulation Of Cardiac Muscle Hypertrophy Calcium Channel Activity Single Fertilization Positive Regulation Of Calcium Ion Transport Detection Of Abiotic Stimulus Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport	Regulation Of Sequestering Of Calcium Ion Calcium Ion Transmembrane Transport Calcium Ion Transport Metal Ion Transport Inositol 1,4,5 Trisphosphate Binding Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Phosphatidylinositol Phospholipase C Activity Negative Regulation Of Sequestering Of Calcium Ion Monoatomic Ion Transport Inorganic Ion Transmembrane Transport Store-operated Calcium Channel Activity Monoatomic Ion Transmembrane Transport Calcium Channel Activity Calcium-mediated Signaling Phospholipase C Activity Regulation Of Metal Ion Transport Regulation Of Transport Regulation Of Calcium Ion Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Insulin Secretion Plasma Membrane Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Calcium Ion Homeostasis Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Intracellular Signal Transduction Positive Regulation Of Transport Calcium Ion Binding Phosphoric Diester Hydrolase Activity Intracellular Signaling Cassette Positive Regulation Of Protein Transport Long-term Synaptic Potentiation Regulation Of Hormone Secretion Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Protein Localization Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion
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