HES4 and PCBD2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		HES4	PCBD2
Description		hes family bHLH transcription factor 4	pterin-4 alpha-carbinolamine dehydratase 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Mitochondrion
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity	Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Lyase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Anterior/posterior Pattern Specification Cell Differentiation	Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549)	Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 18391951 28552196) Type 2 diabetes ( 24509480)
Interacting Genes		5 interacting genes: COPG2 LTN1 PCBD1 PCBD2 RGS3	42 interacting genes: AATF APP ASCC2 BCAS2 BRF1 C1D CDC5L CENPK CERS3 CHAF1A F2RL1 FBXO7 GTF2E1 GUCD1 HES4 IRF2BP1 KCNIP3 KLC3 LGALS14 MAGEA11 MAGEA6 MED21 MED30 MED4 MED7 MET MRFAP1 PBXIP1 PCBD1 PHF14 PML RUNX1T1 SNW1 SPG21 SSX3 SSX5 STAT3 TAL2 TGIF2LY USP2-AS1 XBP1 ZZZ3
Entrez ID		57801	84105
HPRD ID		16273	17824
Ensembl ID		ENSG00000188290	ENSG00000132570
Uniprot IDs		D6REB3 E9PB28 Q9HCC6	Q9H0N5
PDB IDs			4C45
Enriched GO Terms of Interacting Partners?		4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tetrahydrobiopterin Biosynthetic Process Tetrahydrobiopterin Metabolic Process Pteridine-containing Compound Biosynthetic Process Diol Metabolic Process Pteridine-containing Compound Metabolic Process Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Lyase Activity RQC Complex Alcohol Metabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Ribosomal Large Subunit Binding COPI-coated Vesicle COPI Vesicle Coat Tyrosine Metabolic Process COPI-coated Vesicle Membrane Bounding Membrane Of Organelle Small Molecule Biosynthetic Process	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Nucleoplasm Transcription Preinitiation Complex Assembly Transcription Coactivator Activity Core Mediator Complex Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Mediator Complex Negative Regulation Of RNA Metabolic Process Protein-DNA Complex Assembly RNA Polymerase II Preinitiation Complex Assembly Nuclear Vitamin D Receptor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Coregulator Activity Somatic Stem Cell Population Maintenance Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Initiation U2-type Catalytic Step 2 Spliceosome Positive Regulation Of RNA Metabolic Process Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Interleukin-6 Production Regulation Of Interleukin-1 Beta Production Regulation Of DNA-templated Transcription Elongation Negative Regulation Of Metabolic Process Transcription Corepressor Activity Ubiquitin Ligase Complex Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Interleukin-1 Production Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Stem Cell Population Maintenance
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