PCBD2 and IRF2BP1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		PCBD2	IRF2BP1
Description		pterin-4 alpha-carbinolamine dehydratase 2	interferon regulatory factor 2 binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Nucleus Nucleoplasm
	Molecular Function	Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Lyase Activity	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 18391951 28552196) Type 2 diabetes ( 24509480)	Apolipoprotein A1 levels ( 32203549) Asthma ( 31959851) Gallstone disease ( 30504769) HDL cholesterol levels ( 32203549) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		42 interacting genes: AATF APP ASCC2 BCAS2 BRF1 C1D CDC5L CENPK CERS3 CHAF1A F2RL1 FBXO7 GTF2E1 GUCD1 HES4 IRF2BP1 KCNIP3 KLC3 LGALS14 MAGEA11 MAGEA6 MED21 MED30 MED4 MED7 MET MRFAP1 PBXIP1 PCBD1 PHF14 PML RUNX1T1 SNW1 SPG21 SSX3 SSX5 STAT3 TAL2 TGIF2LY USP2-AS1 XBP1 ZZZ3	9 interacting genes: ATF2 CEBPA IRF2 IRF9 JDP2 PCBD2 SMAD1 TGIF1 UBE2L3
Entrez ID		84105	26145
HPRD ID		17824	17159
Ensembl ID		ENSG00000132570	ENSG00000170604
Uniprot IDs		Q9H0N5	Q8IU81
PDB IDs		4C45
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Nucleoplasm Transcription Preinitiation Complex Assembly Transcription Coactivator Activity Core Mediator Complex Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Mediator Complex Negative Regulation Of RNA Metabolic Process Protein-DNA Complex Assembly RNA Polymerase II Preinitiation Complex Assembly Nuclear Vitamin D Receptor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Coregulator Activity Somatic Stem Cell Population Maintenance Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Initiation U2-type Catalytic Step 2 Spliceosome Positive Regulation Of RNA Metabolic Process Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Interleukin-6 Production Regulation Of Interleukin-1 Beta Production Regulation Of DNA-templated Transcription Elongation Negative Regulation Of Metabolic Process Transcription Corepressor Activity Ubiquitin Ligase Complex Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Interleukin-1 Production Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Stem Cell Population Maintenance	DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cell Population Proliferation Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA Binding Regulation Of Primary Metabolic Process Leucine Zipper Domain Binding CAMP Response Element Binding Co-SMAD Binding Fat Cell Differentiation White Fat Cell Differentiation Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Binding Regulation Of Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Abducens Nucleus Development Hypoglossal Nucleus Development Protein Heterodimerization Activity Positive Regulation Of Osteoblast Differentiation Nucleobase-containing Compound Biosynthetic Process
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