PTPN2 and MRPS7

		PTPN2	MRPS7
Description		protein tyrosine phosphatase non-receptor type 2	mitochondrial ribosomal protein S7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Membrane Endosome Lumen	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit Ribosome Ribonucleoprotein Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding Hydrolase Activity Protein Kinase Binding Syntaxin Binding Receptor Tyrosine Kinase Binding STAT Family Protein Binding	RNA Binding MRNA Binding Structural Constituent Of Ribosome RRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Lipid Storage B Cell Differentiation T Cell Differentiation Erythrocyte Differentiation Peptidyl-tyrosine Dephosphorylation Insulin Receptor Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Glucose Homeostasis Negative Regulation Of Macrophage Differentiation Positive Regulation Of Gluconeogenesis Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Chemotaxis Regulation Of Type II Interferon-mediated Signaling Pathway Negative Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-2-mediated Signaling Pathway Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Negative Regulation Of Positive Thymic T Cell Selection Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Translation Mitochondrial Translation
Pathways		Negative regulation of MET activity Interleukin-37 signaling PKR-mediated signaling	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Drugs
Diseases		Type I diabetes mellitus
GWAS		Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Body mass index ( 25673413) C-reactive protein levels ( 30388399 21300955) Celiac disease ( 20190752 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17554261 28067908 25489960 21102463 17554300 18587394) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Esophageal cancer (squamous cell) ( 22960999) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lead levels in blood ( 25820613) Lymphocyte count ( 32888494) Mean reticulocyte volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Psoriasis ( 28537254) Red blood cell count ( 32888494) Rheumatoid arthritis ( 30423114 24390342 23143596 22446963) Rheumatoid arthritis (ACPA-positive) ( 24532676) Selective IgA deficiency ( 27723758) Type 1 diabetes ( 25751624 21829393 19430480 18978792 17554260)
Interacting Genes		31 interacting genes: CDK1 CDK2 CDK5 COLEC12 CRYAA EGFR FAM220A FKBP4 GHR GJB1 HMGB1 INSR ITGA1 JAK1 JAK3 KPNB1 MRPS7 OCLN PDGFRB PTMA SHC1 SRC SRPK1 STAT1 STAT3 STAT5A STAT5B STX17 TMEM132D UBC ZBTB14	4 interacting genes: ASXL1 PTEN PTPN2 UBC
Entrez ID		5771	51081
HPRD ID		06768	17601
Ensembl ID		ENSG00000175354	ENSG00000125445
Uniprot IDs		A8K3N4 K7EQG9 P17706 Q59F91	Q9Y2R9
PDB IDs		1L8K 6ZZ4 7F5N 7F5O 7UAD 8U0H 8UH6 9C54 9C55 9C56	3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K 7L08 7OG4 7P2E 7PNX 7PNY 7PNZ 7PO0 7PO1 7PO2 7PO3 7QI4 7QI5 7QI6 8ANY 8CSP 8CSQ 8CSR 8CSS 8CST 8CSU 8K2A 8OIR 8OIS 8QRK 8QRL 8QRM 8QRN 8RRI 8XT0 8XT2
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Signaling Pathway Via JAK-STAT Interleukin-9-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Phosphatase Binding Interleukin-7-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Phosphorylation Positive Regulation Of Cell Population Proliferation Kinase Activity Protein Tyrosine Kinase Activity Protein Phosphorylation Interleukin-4-mediated Signaling Pathway Positive Regulation Of Growth CCR5 Chemokine Receptor Binding Response To Cytokine Regulation Of Apoptotic Process Response To Peptide Cytokine-mediated Signaling Pathway Regulation Of Programmed Cell Death Taurine Metabolic Process Regulation Of Growth Regulation Of Macromolecule Biosynthetic Process Response To Peptide Hormone Positive Regulation Of MAPK Cascade Regulation Of Developmental Growth Positive Regulation Of Myeloid Cell Differentiation Nuclear Glucocorticoid Receptor Binding Regulation Of Erythrocyte Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Tyrosine Kinase Activator Activity Shc-EGFR Complex Interleukin-6-mediated Signaling Pathway Response To Interleukin-15 Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Regulation Of Multicellular Organism Growth Regulation Of Macromolecule Metabolic Process	Negative Regulation Of Synaptic Vesicle Clustering Protein Dephosphorylation Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Phosphoprotein Phosphatase Activity Dephosphorylation Negative Regulation Of Cell Differentiation Negative Regulation Of Phosphorylation Negative Regulation Of Protein Phosphorylation Protein Tyrosine Phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Interleukin-2-mediated Signaling Pathway Negative Regulation Of Developmental Process Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Negative Regulation Of Phosphate Metabolic Process Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Insulin Receptor Recycling PR-DUB Complex Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Positive Regulation Of Intracellular Signal Transduction Phosphatidylinositol Phosphate Phosphatase Activity Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Interleukin-6-mediated Signaling Pathway Lung Saccule Development Regulation Of Kidney Size Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Cell Development Postsynaptic Density Assembly Negative Regulation Of Type II Interferon-mediated Signaling Pathway Bone Marrow Development Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Locomotor Rhythm Nucleoplasm Negative Regulation Of Locomotion Regulation Of Cell Differentiation Cellular Response To Electrical Stimulus Regulation Of Protein Phosphorylation
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