PTPN2 and COLEC12

		PTPN2	COLEC12
Description		protein tyrosine phosphatase non-receptor type 2	collectin subfamily member 12
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Membrane Endosome Lumen	Collagen Trimer Plasma Membrane Membrane Endocytic Vesicle Membrane Extracellular Matrix
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding Hydrolase Activity Protein Kinase Binding Syntaxin Binding Receptor Tyrosine Kinase Binding STAT Family Protein Binding	Scavenger Receptor Activity Protein Binding Galactose Binding Low-density Lipoprotein Particle Binding Carbohydrate Binding Pattern Recognition Receptor Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Lipid Storage B Cell Differentiation T Cell Differentiation Erythrocyte Differentiation Peptidyl-tyrosine Dephosphorylation Insulin Receptor Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Glucose Homeostasis Negative Regulation Of Macrophage Differentiation Positive Regulation Of Gluconeogenesis Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Chemotaxis Regulation Of Type II Interferon-mediated Signaling Pathway Negative Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-2-mediated Signaling Pathway Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Negative Regulation Of Positive Thymic T Cell Selection Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Regulation Of Immune System Process Phagocytosis, Recognition Defense Response Immune Response Carbohydrate Mediated Signaling Defense Response To Bacterium Plasma Membrane Raft Organization Innate Immune Response
Pathways		Negative regulation of MET activity Interleukin-37 signaling PKR-mediated signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Scavenging by Class A Receptors
Drugs
Diseases		Type I diabetes mellitus
GWAS		Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Body mass index ( 25673413) C-reactive protein levels ( 30388399 21300955) Celiac disease ( 20190752 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17554261 28067908 25489960 21102463 17554300 18587394) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Esophageal cancer (squamous cell) ( 22960999) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lead levels in blood ( 25820613) Lymphocyte count ( 32888494) Mean reticulocyte volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Psoriasis ( 28537254) Red blood cell count ( 32888494) Rheumatoid arthritis ( 30423114 24390342 23143596 22446963) Rheumatoid arthritis (ACPA-positive) ( 24532676) Selective IgA deficiency ( 27723758) Type 1 diabetes ( 25751624 21829393 19430480 18978792 17554260)	Bipolar disorder ( 20351715) Bipolar disorder or major depressive disorder ( 20351715) Blood protein levels ( 30072576) Coenzyme Q10 levels ( 27149984) Metabolic syndrome ( 29212154) Obesity-related traits ( 23251661) Schizophrenia x sex interaction ( 34099189) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		31 interacting genes: CDK1 CDK2 CDK5 COLEC12 CRYAA EGFR FAM220A FKBP4 GHR GJB1 HMGB1 INSR ITGA1 JAK1 JAK3 KPNB1 MRPS7 OCLN PDGFRB PTMA SHC1 SRC SRPK1 STAT1 STAT3 STAT5A STAT5B STX17 TMEM132D UBC ZBTB14	6 interacting genes: APP EXOC1 EXOSC2 FBXO7 PTPN2 ZBTB14
Entrez ID		5771	81035
HPRD ID		06768	06358
Ensembl ID		ENSG00000175354	ENSG00000158270
Uniprot IDs		A8K3N4 K7EQG9 P17706 Q59F91	Q5KU26
PDB IDs		1L8K 6ZZ4 7F5N 7F5O 7UAD 8U0H 8UH6 9C54 9C55 9C56	2OX8
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Signaling Pathway Via JAK-STAT Interleukin-9-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Phosphatase Binding Interleukin-7-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Phosphorylation Positive Regulation Of Cell Population Proliferation Kinase Activity Protein Tyrosine Kinase Activity Protein Phosphorylation Interleukin-4-mediated Signaling Pathway Positive Regulation Of Growth CCR5 Chemokine Receptor Binding Response To Cytokine Regulation Of Apoptotic Process Response To Peptide Cytokine-mediated Signaling Pathway Regulation Of Programmed Cell Death Taurine Metabolic Process Regulation Of Growth Regulation Of Macromolecule Biosynthetic Process Response To Peptide Hormone Positive Regulation Of MAPK Cascade Regulation Of Developmental Growth Positive Regulation Of Myeloid Cell Differentiation Nuclear Glucocorticoid Receptor Binding Regulation Of Erythrocyte Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Tyrosine Kinase Activator Activity Shc-EGFR Complex Interleukin-6-mediated Signaling Pathway Response To Interleukin-15 Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Regulation Of Multicellular Organism Growth Regulation Of Macromolecule Metabolic Process	Regulation Of Intrinsic Apoptotic Signaling Pathway Endosome Lumen Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Interleukin-2-mediated Signaling Pathway Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Response To Endoplasmic Reticulum Stress Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Integrin Binding Regulation Of Immune System Process Regulation Of Cell Activation Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Lipoprotein Particle Cytosol Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Protein Import Cell Activation Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Interleukin-4-mediated Signaling Pathway Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Hemopoiesis Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Lewy Body Core Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Positive Regulation Of Small Molecule Metabolic Process Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of PERK-mediated Unfolded Protein Response
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