CHD8 and TOP3B

Number of citations of the paper that reports this interaction (PubMedID 11549288)
0

Data Source:
HPRD (two hybrid)

		CHD8	TOP3B
Description		chromodomain helicase DNA binding protein 8	DNA topoisomerase III beta
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Protein-containing Complex MLL1 Complex	Condensed Chromosome Nucleus DNA Topoisomerase III-beta-TDRD3 Complex
	Molecular Function	Nucleotide Binding P53 Binding DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Beta-catenin Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Histone Binding Histone H3K4me3 Reader Activity ATP-dependent Chromatin Remodeler Activity	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding Isomerase Activity RNA Topoisomerase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Startle Response Chromatin Organization Chromatin Remodeling MRNA Processing Brain Development Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Social Behavior Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Digestive Tract Development Prepulse Inhibition Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process	DNA Topological Change DNA Repair DNA Recombination Chromosome Segregation
Pathways		Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172)	Attention function in attention deficit hyperactive disorder ( 26174813) Bipolar disorder ( 31043756) Diastolic blood pressure ( 29208002) Response to selective serotonin reuptake inhibitors in depression ( 27622933)
Interacting Genes		12 interacting genes: AR CEBPA CHD7 CREB1 CTCF CTNNB1 MYC RBBP5 RCHY1 SUMO2 TOP3B WDR5	25 interacting genes: ADAMTSL4 AXIN2 C1QBP CENPF CHD8 CHIC2 CIAO1 FASTK FBLN5 GPRASP3 GRN KANK2 KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TDRD3 TRIM41 UPF2 ZFPM1 ZNF250 ZNF408
Entrez ID		57680	8940
HPRD ID		16712	04662
Ensembl ID		ENSG00000100888	ENSG00000100038
Uniprot IDs		Q9HCK8	A8K4N2 O95985
PDB IDs		2CKA 2DL6	5GVC 5GVE 9C9W 9C9Y 9CA0 9CA1 9CA4 9CAG 9CAH 9CAJ 9CAK 9CAL
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleoplasm Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Transcription Coregulator Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Centromeric Sister Chromatid Cohesion Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Euchromatin Chromatin Binding Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of DNA-templated Transcription Initiation MLL1/2 Complex In Utero Embryonic Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Chordate Embryonic Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Genitalia Morphogenesis Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression MLL3/4 Complex Regulation Of Fibroblast Proliferation Response To Xenobiotic Stimulus Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
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