CHD8 and RBBP5

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (two hybrid, biochemical)

		CHD8	RBBP5
Description		chromodomain helicase DNA binding protein 8	RB binding protein 5, histone lysine methyltransferase complex subunit
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Protein-containing Complex MLL1 Complex	Nucleus Nucleoplasm Nucleolus Histone Methyltransferase Complex MLL1/2 Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	Nucleotide Binding P53 Binding DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Beta-catenin Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Histone Binding Histone H3K4me3 Reader Activity ATP-dependent Chromatin Remodeler Activity	Transcription Cis-regulatory Region Binding Protein Binding Histone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Startle Response Chromatin Organization Chromatin Remodeling MRNA Processing Brain Development Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Social Behavior Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Digestive Tract Development Prepulse Inhibition Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process	Chromatin Organization DNA Damage Response Response To Estrogen Transcription Initiation-coupled Chromatin Remodeling
Pathways		Deactivation of the beta-catenin transactivating complex	Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Neddylation Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172)	Basophil percentage of granulocytes ( 27863252) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Mean platelet volume ( 24026423 32888494) Meat-related diet ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549)
Interacting Genes		12 interacting genes: AR CEBPA CHD7 CREB1 CTCF CTNNB1 MYC RBBP5 RCHY1 SUMO2 TOP3B WDR5	13 interacting genes: CHD8 CTBP1 CTNNB1 H3-4 H3C14 KMT2A KMT2B MEN1 PTEN RB1 RBM39 UBE2I WDR5
Entrez ID		57680	5929
HPRD ID		16712	02826
Ensembl ID		ENSG00000100888	ENSG00000117222
Uniprot IDs		Q9HCK8	B4DLF8 Q15291
PDB IDs		2CKA 2DL6	3P4F 4X8N 4X8P 5F6K 5F6L 6KIU 6KIV 6KIW 6KIX 6KIZ 6KM7 6PWV 6PWW 6PWX 6W5I 6W5M 6W5N 7BRE 7MBM 7MBN 7UD5 7W67 7W6A 7W6I 7W6J 7W6L 8DU4
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleoplasm Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Transcription Coregulator Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Centromeric Sister Chromatid Cohesion Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Euchromatin Chromatin Binding Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of DNA-templated Transcription Initiation MLL1/2 Complex In Utero Embryonic Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Chordate Embryonic Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Genitalia Morphogenesis Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression MLL3/4 Complex Regulation Of Fibroblast Proliferation Response To Xenobiotic Stimulus Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation	MLL1/2 Complex Nucleoplasm Histone Methyltransferase Complex Chromatin Remodeling MLL1 Complex Chromatin Organization Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Histone H3K4 Methyltransferase Activity Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression, Epigenetic Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone H3K4 Monomethyltransferase Activity T-helper 2 Cell Differentiation Unmethylated CpG Binding Histone H3K4 Trimethyltransferase Activity Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Synaptic Vesicle Clustering Presynaptic Active Zone Cytoplasmic Component Epigenetic Regulation Of Gene Expression Prepulse Inhibition Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of Protein Phosphorylation PML Body Positive Regulation Of Macromolecule Metabolic Process
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