AARS2 and MEGF10

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		AARS2	MEGF10
Description		alanyl-tRNA synthetase 2, mitochondrial	multiple EGF like domains 10
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion	Phagocytic Cup Plasma Membrane Membrane Cell Projection
	Molecular Function	TRNA Binding Nucleotide Binding Aminoacyl-tRNA Deacylase Activity Nucleic Acid Binding RNA Binding Aminoacyl-tRNA Ligase Activity Alanine-tRNA Ligase Activity Protein Binding ATP Binding Zinc Ion Binding Ligase Activity Metal Ion Binding Peptide Lactyltransferase (ATP-dependent) Activity	Complement Component C1q Complex Binding Scavenger Receptor Activity Notch Binding
	Biological Process	Translation Alanyl-tRNA Aminoacylation TRNA Aminoacylation Mitochondrial Alanyl-tRNA Aminoacylation Aminoacyl-tRNA Metabolism Involved In Translational Fidelity CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway	Phagocytosis Cell Adhesion Muscle Organ Development Skeletal Muscle Satellite Cell Activation Skeletal Muscle Satellite Cell Differentiation Skeletal Muscle Satellite Cell Proliferation Vesicle-mediated Transport Positive Regulation Of Cell-cell Adhesion Muscle Cell Proliferation Homotypic Cell-cell Adhesion Apoptotic Cell Clearance Engulfment Of Apoptotic Cell Recognition Of Apoptotic Cell Cell Development Myoblast Development Regulation Of Skeletal Muscle Tissue Development Regulation Of Muscle Cell Differentiation Myoblast Migration Muscle Cell Development Apoptotic Process Involved In Development Positive Regulation Of Myoblast Proliferation
Pathways		Mitochondrial tRNA aminoacylation
Drugs		Alanine
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) Appendicular lean mass ( 33097823) Bone mineral content ( 31790847) Chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) Hearing loss in Charcot-Marie-Tooth disease 1A ( 30958311) Initial pursuit acceleration ( 29064472) Response to antipsychotic treatment in schizophrenia ( 29503163)
Interacting Genes		4 interacting genes: EHHADH MEGF10 RNF10 YWHAQ	24 interacting genes: AARS2 ALMS1 AP2M1 ARHGAP32 BAHD1 CADPS2 CEP57 CUL7 DHX16 GRB10 GULP1 HDAC4 ITSN2 MCF2L2 RANBP10 SART3 SCAPER SHANK3 SHTN1 SNRNP200 TAOK2 TMEM132A VWA8 ZNFX1
Entrez ID		57505	84466
HPRD ID		12397	14384
Ensembl ID		ENSG00000124608	ENSG00000145794
Uniprot IDs		Q5JTZ9	Q96KG7
PDB IDs		6NLQ 6NLY 6NOW
Enriched GO Terms of Interacting Partners?		Enoyl-CoA Hydratase Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Delta(3)-delta(2)-enoyl-CoA Isomerase Activity 3-hydroxyacyl-CoA Dehydratase Activity Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Engulfment Of Apoptotic Cell Recognition Of Apoptotic Cell Skeletal Muscle Satellite Cell Differentiation Skeletal Muscle Satellite Cell Proliferation Complement Component C1q Complex Binding Myoblast Development Skeletal Muscle Satellite Cell Activation Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Skeletal Muscle Cell Proliferation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Phagocytosis, Recognition Myoblast Migration Alpha-linolenic Acid Metabolic Process Positive Regulation Of Myoblast Proliferation Negative Regulation Of Glial Cell Proliferation NAD+ Binding Positive Regulation Of Myelination Regulation Of Myoblast Proliferation Regulation Of Skeletal Muscle Tissue Development Scavenger Receptor Activity Notch Binding Apoptotic Cell Clearance Muscle Cell Migration Phagocytic Cup Phagocytosis, Engulfment	Cytoplasm
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