AARS2

Description		alanyl-tRNA synthetase 2, mitochondrial
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion
	Molecular Function	TRNA Binding Nucleotide Binding Aminoacyl-tRNA Deacylase Activity Nucleic Acid Binding RNA Binding Aminoacyl-tRNA Ligase Activity Alanine-tRNA Ligase Activity Protein Binding ATP Binding Zinc Ion Binding Ligase Activity Metal Ion Binding Peptide Lactyltransferase (ATP-dependent) Activity
	Biological Process	Translation Alanyl-tRNA Aminoacylation TRNA Aminoacylation Mitochondrial Alanyl-tRNA Aminoacylation Aminoacyl-tRNA Metabolism Involved In Translational Fidelity CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway
Pathways		Mitochondrial tRNA aminoacylation
Drugs		Alanine
Diseases
GWAS
Novel Interacting Genes		4 novel interacting genes: EHHADH MEGF10 RNF10 YWHAQ
Interacting Genes		4 interacting genes: EHHADH MEGF10 RNF10 YWHAQ
Entrez ID		57505
HPRD ID		12397
Ensembl ID		ENSG00000124608
Uniprot IDs		Q5JTZ9
PDB IDs		6NLQ 6NLY 6NOW
Enriched GO Terms of Interacting Partners?		Enoyl-CoA Hydratase Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Delta(3)-delta(2)-enoyl-CoA Isomerase Activity 3-hydroxyacyl-CoA Dehydratase Activity Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Engulfment Of Apoptotic Cell Recognition Of Apoptotic Cell Skeletal Muscle Satellite Cell Differentiation Skeletal Muscle Satellite Cell Proliferation Complement Component C1q Complex Binding Myoblast Development Skeletal Muscle Satellite Cell Activation Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Skeletal Muscle Cell Proliferation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Phagocytosis, Recognition Myoblast Migration Alpha-linolenic Acid Metabolic Process Positive Regulation Of Myoblast Proliferation Negative Regulation Of Glial Cell Proliferation NAD+ Binding Positive Regulation Of Myelination Regulation Of Myoblast Proliferation Regulation Of Skeletal Muscle Tissue Development Scavenger Receptor Activity Notch Binding Apoptotic Cell Clearance Muscle Cell Migration Phagocytic Cup Phagocytosis, Engulfment
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