MRTFB and ERC1

		MRTFB	ERC1
Description		myocardin related transcription factor B	ELKS/RAB6-interacting/CAST family member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Presynapse Postsynapse Glutamatergic Synapse	Golgi Membrane Podosome Cytoplasm Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane IkappaB Kinase Complex Membrane Ciliary Basal Body Presynaptic Membrane Cell Projection Synapse Anchoring Junction Presynapse Presynaptic Active Zone Cytoplasmic Component
	Molecular Function	Transcription Coactivator Activity Protein Binding Cadherin Binding	Protein Binding PDZ Domain Binding Small GTPase Binding Cadherin Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Muscle Organ Development Cell Differentiation Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Cell Differentiation Regulation Of Modification Of Postsynaptic Structure Positive Regulation Of MiRNA Transcription	Regulation Of DNA-templated Transcription I-kappaB Phosphorylation Protein Transport Retrograde Transport, Endosome To Golgi Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297) Body mass index ( 26426971) Femur bone mineral density x serum urate levels interaction ( 34046847) Forehead morphology ( 29921221) Height ( 29782485) Lumbar spine bone mineral density ( 22504420) Medial temporal lobe substructure volumes ( 32768867) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		12 interacting genes: CPPED1 ERC1 FCGR2B KDM3A KPNA4 MRTFA NCOA3 SHISA9 SMAD1 SMAD7 SRF SVIL	21 interacting genes: APP CD163 CRIP1 DNAJC5 DYRK1A FGF23 FPR2 GALNT8 GPRC5D IFFO1 ITSN2 MRTFB NCAPD2 PPFIA1 PRMT8 RAB6A RAB6B RIMS1 SRPK2 UBC YWHAG
Entrez ID		57496	23085
HPRD ID		17577	06181
Ensembl ID		ENSG00000186260	ENSG00000082805
Uniprot IDs		I3L2S3 Q9ULH7	G8JLD3 Q8IUD2 X6RLX0 X6RM00
PDB IDs
Enriched GO Terms of Interacting Partners?		Male Germ Cell Nucleus Heteromeric SMAD Protein Complex Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Primary MiRNA Binding Positive Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process I-SMAD Binding SMAD Protein Signal Transduction Muscle Tissue Development Smooth Muscle Cell Differentiation Positive Regulation Of Cartilage Development Regulation Of B Cell Antigen Processing And Presentation Regulation Of Cell Differentiation Positive Regulation Of Multicellular Organismal Process Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Ureteric Bud Development Epithelium Development Mesonephric Epithelium Development Chromatin Mesonephric Tubule Development Beta-catenin Destruction Complex Disassembly Positive Regulation Of Chondrocyte Hypertrophy Serum Response Element Binding Podosome Formaldehyde Biosynthetic Process Artery Morphogenesis Negative Regulation Of Cell Population Proliferation Cellular Developmental Process Negative Regulation Of Adaptive Immune Response Low-affinity IgG Receptor Activity Tissue Development Homomeric SMAD Protein Complex Regulation Of Cartilage Development Kidney Epithelium Development Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Chondrocyte Development Bronchus Cartilage Development Lung Smooth Muscle Development Regulation Of Stem Cell Population Maintenance PDZ Domain Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Cytotoxic T Cell Degranulation Regulation Of Multicellular Organismal Development	Presynapse Endosome To Plasma Membrane Transport Vesicle Protein Localization To Golgi Membrane Vesicle-mediated Transport RAGE Receptor Binding Regulation Of Neuron Apoptotic Process Astrocyte Activation Positive Regulation Of Superoxide Anion Generation Myosin V Binding Positive Regulation Of Dendrite Extension Vesicle-mediated Transport In Synapse Regulation Of Modification Of Synaptic Structure Regulation Of Modification Of Postsynaptic Structure Regulation Of Superoxide Anion Generation Positive Regulation Of Monocyte Chemotaxis Protein Localization To Golgi Apparatus Regulation Of Superoxide Metabolic Process Microglial Cell Activation Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Monocyte Chemotaxis Leukocyte Activation Involved In Inflammatory Response Synaptic Vesicle Exocytosis Intra-Golgi Vesicle-mediated Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Histone H3T45 Kinase Activity Peptidyl-cysteine Methylation Protein Methylation Positive Regulation Of Vitamin D 24-hydroxylase Activity Presynaptic Active Zone Positive Chemotaxis Regulation Of Cellular Component Organization Positive Regulation Of ERK1 And ERK2 Cascade Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Modulation Of Excitatory Postsynaptic Potential
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