BIRC6 and ALK

		BIRC6	ALK
Description		baculoviral IAP repeat containing 6	ALK receptor tyrosine kinase
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GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Membrane Midbody Flemming Body	Plasma Membrane Membrane Protein-containing Complex Receptor Complex Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Transferase Activity Peptidase Inhibitor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Heparin Binding Kinase Activity Transferase Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity Identical Protein Binding
	Biological Process	Placenta Development Protein Phosphorylation Apoptotic Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Regulation Of Cytokinesis Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Cell Division Labyrinthine Layer Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Response To Stress Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Brain Development Phosphorylation Hippocampus Development Adult Behavior Swimming Behavior Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Protein Autophosphorylation Neuron Development Negative Regulation Of Lipid Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Primary Metabolic Process Response To Environmental Enrichment Energy Homeostasis Positive Regulation Of Dendrite Development
Pathways		ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants	Signaling by ALK Signaling by ALK ALK mutants bind TKIs ASP-3026-resistant ALK mutants NVP-TAE684-resistant ALK mutants alectinib-resistant ALK mutants brigatinib-resistant ALK mutants ceritinib-resistant ALK mutants crizotinib-resistant ALK mutants lorlatinib-resistant ALK mutants Signaling by ALK fusions and activated point mutants MDK and PTN in ALK signaling MDK and PTN in ALK signaling
Drugs			ATP Crizotinib Ceritinib Alectinib Fostamatinib Lorlatinib Gilteritinib Brigatinib
Diseases			Non-small cell lung cancer
GWAS		Chronotype ( 30696823) Coffee consumption ( 31046077) General risk tolerance (MTAG) ( 30643258) Male-pattern baldness ( 28196072) Red cell distribution width ( 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258)	Adiponectin levels (BMI-adjusted) ( 26299439) Body mass index ( 25673413) Body size at age 10 ( 32376654) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027) Carbamazepine-induced serious cutaneous adverse reaction ( 31066027) Dentures ( 31235808) Gestational age at birth (child effect) ( 31194736) Glucose homeostasis traits ( 25524916) Low density lipoprotein cholesterol levels ( 33339817) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pre-treatment viral load in HIV-1 infection ( 31219150) Simvastatin-induced myopathy ( 31220337) Spontaneous coronary artery dissection ( 32887874) Systolic blood pressure ( 26969751) Total cholesterol levels ( 33339817)
Interacting Genes		30 interacting genes: ALK ARIH1 BIRC2 BIRC5 CASP3 CASP8 CASP9 CDK1 CSNK2A1 DIABLO EXOC3 EXOC4 GABARAP HTRA2 MAP1LC3B MAP2K1 NEDD4 PLK1 RAB8A RACK1 RNF144A RNF4 RNF41 UBA6 UBC UBE2D1 UBE3C USP8 VAV2 VCL	31 interacting genes: APBB1 BIRC6 CLNS1A DLG2 DNMT3A DUSP19 ERBB2 HADHB HES1 HMGB1 IKBKG IRS1 JAK3 MDK MSH2 NLRC4 NPM1 PIK3R1 PLCG1 PPM1A PTN PTPN11 PTPRZ1 RASA1 SHC1 SHC3 SMC1A TNFRSF8 TSPAN16 TTC19 ZC3HC1
Entrez ID		57448	238
HPRD ID		05731	00104
Ensembl ID		ENSG00000115760	ENSG00000171094
Uniprot IDs		A0A8V8TQB4 A0A8V8TR92 Q9NR09	A0A0K2YUJ3 B6D4Y2 Q9UM73
PDB IDs		3CEG 8ATM 8ATO 8ATU 8ATX 8AUK 8AUW 8E2D 8E2E 8E2F 8E2G 8E2H 8E2I 8E2K	2KUP 2KUQ 2XB7 2XBA 2XP2 2YFX 2YHV 2YJR 2YJS 2YS5 2YT2 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4CCB 4CCU 4CD0 4CLI 4CLJ 4CMO 4CMT 4CMU 4CNH 4CTB 4CTC 4DCE 4FNW 4FNX 4FNY 4FNZ 4FOB 4FOC 4FOD 4JOA 4MKC 4TT7 4Z55 5A9U 5AA8 5AA9 5AAA 5AAB 5AAC 5FTO 5FTQ 5IMX 5IUG 5IUH 5IUI 5KZ0 5VZ5 6AT9 6CDT 6E0R 6EBW 6EDL 6MX8 7BTT 7JY4 7JYR 7JYS 7JYT 7LRZ 7LS0 7MZW 7MZY 7N00 7NWZ 7NX3 7NX4 7R7K 7R7R 8ARJ 9G5I 9GBE
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Ubiquitination Proteolysis Cytosol Protein Modification By Small Protein Conjugation Protein Modification Process Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process Intracellular Signal Transduction Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Apoptotic Process Catabolic Process Programmed Cell Death Cell Death Midbody Mitotic Cytokinesis Response To Anesthetic Execution Phase Of Apoptosis Ubiquitin Protein Ligase Activity Regulation Of Autophagy Regulation Of Apoptotic Process Modification-dependent Protein Catabolic Process Regulation Of Programmed Cell Death Protein Polyubiquitination Cytoskeleton-dependent Cytokinesis Response To Cobalt Ion CD40 Receptor Complex Regulation Of Macroautophagy Apoptotic Signaling Pathway Positive Regulation Of Protein Catabolic Process Signal Transduction Regulation Of Protein Localization Cytoplasm Transferase Activity Regulation Of Protein Catabolic Process Golgi Inheritance Positive Regulation Of Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Regulation Of Protein Metabolic Process Cysteine-type Endopeptidase Activity DNA Damage Response Cellular Response To Stress Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Localization To Site Of Double-strand Break Macromolecule Metabolic Process	Regulation Of Apoptotic Process Phosphotyrosine Residue Binding Regulation Of Programmed Cell Death Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Insulin Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Negative Regulation Of Apoptotic Process ERBB Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Development Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Cell Adhesion Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Hemopoiesis Negative Regulation Of T Cell Differentiation Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Positive Regulation Of Biosynthetic Process Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of T Cell Activation Receptor Tyrosine Kinase Binding Leukocyte Activation Positive Regulation Of Gliogenesis Intracellular Signal Transduction Positive Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Glial Cell Differentiation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Immune System Process Leukocyte Activation Involved In Immune Response Negative Regulation Of Leukocyte Cell-cell Adhesion Cell Activation Involved In Immune Response Cellular Response To Growth Factor Stimulus Regulation Of Immune System Process Negative Regulation Of Lymphocyte Activation Lymphocyte Activation Cell Activation Response To Growth Factor Negative Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Development Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Leukocyte Activation Insulin-like Growth Factor Receptor Signaling Pathway
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