ALK and HADHB

Number of citations of the paper that reports this interaction (PubMedID 35384245)
105

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)

		ALK	HADHB
Description		ALK receptor tyrosine kinase	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Protein-containing Complex Receptor Complex Extracellular Exosome	Nucleoplasm Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Mitochondrial Inner Membrane Endoplasmic Reticulum Membrane Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Mitochondrial Nucleoid
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Heparin Binding Kinase Activity Transferase Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity Identical Protein Binding	RNA Binding (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Acetyl-CoA C-acetyltransferase Activity Acetyl-CoA C-acyltransferase Activity Enoyl-CoA Hydratase Activity Protein Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Protein-containing Complex Binding Acetyl-CoA C-myristoyltransferase Activity LncRNA Binding
	Biological Process	Response To Stress Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Brain Development Phosphorylation Hippocampus Development Adult Behavior Swimming Behavior Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Protein Autophosphorylation Neuron Development Negative Regulation Of Lipid Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Primary Metabolic Process Response To Environmental Enrichment Energy Homeostasis Positive Regulation Of Dendrite Development	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Gene Expression Cellular Response To Lipopolysaccharide
Pathways		Signaling by ALK Signaling by ALK ALK mutants bind TKIs ASP-3026-resistant ALK mutants NVP-TAE684-resistant ALK mutants alectinib-resistant ALK mutants brigatinib-resistant ALK mutants ceritinib-resistant ALK mutants crizotinib-resistant ALK mutants lorlatinib-resistant ALK mutants Signaling by ALK fusions and activated point mutants MDK and PTN in ALK signaling MDK and PTN in ALK signaling	Acyl chain remodeling of CL Beta oxidation of myristoyl-CoA to lauroyl-CoA mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of palmitoyl-CoA to myristoyl-CoA Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Drugs		ATP Crizotinib Ceritinib Alectinib Fostamatinib Lorlatinib Gilteritinib Brigatinib
Diseases		Non-small cell lung cancer
GWAS		Adiponectin levels (BMI-adjusted) ( 26299439) Body mass index ( 25673413) Body size at age 10 ( 32376654) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027) Carbamazepine-induced serious cutaneous adverse reaction ( 31066027) Dentures ( 31235808) Gestational age at birth (child effect) ( 31194736) Glucose homeostasis traits ( 25524916) Low density lipoprotein cholesterol levels ( 33339817) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pre-treatment viral load in HIV-1 infection ( 31219150) Simvastatin-induced myopathy ( 31220337) Spontaneous coronary artery dissection ( 32887874) Systolic blood pressure ( 26969751) Total cholesterol levels ( 33339817)
Interacting Genes		31 interacting genes: APBB1 BIRC6 CLNS1A DLG2 DNMT3A DUSP19 ERBB2 HADHB HES1 HMGB1 IKBKG IRS1 JAK3 MDK MSH2 NLRC4 NPM1 PIK3R1 PLCG1 PPM1A PTN PTPN11 PTPRZ1 RASA1 SHC1 SHC3 SMC1A TNFRSF8 TSPAN16 TTC19 ZC3HC1	19 interacting genes: ALK ANXA7 APP CDC42 CDKN1A CEBPA CHCHD4 COX17 DDX17 GRB7 HSD17B10 HSPB2 RCC1 SMN1 SUOX TIMM8B TK1 TNNI3K UBC
Entrez ID		238	3032
HPRD ID		00104	00887
Ensembl ID		ENSG00000171094	ENSG00000138029
Uniprot IDs		A0A0K2YUJ3 B6D4Y2 Q9UM73	F5GZQ3 P55084
PDB IDs		2KUP 2KUQ 2XB7 2XBA 2XP2 2YFX 2YHV 2YJR 2YJS 2YS5 2YT2 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4CCB 4CCU 4CD0 4CLI 4CLJ 4CMO 4CMT 4CMU 4CNH 4CTB 4CTC 4DCE 4FNW 4FNX 4FNY 4FNZ 4FOB 4FOC 4FOD 4JOA 4MKC 4TT7 4Z55 5A9U 5AA8 5AA9 5AAA 5AAB 5AAC 5FTO 5FTQ 5IMX 5IUG 5IUH 5IUI 5KZ0 5VZ5 6AT9 6CDT 6E0R 6EBW 6EDL 6MX8 7BTT 7JY4 7JYR 7JYS 7JYT 7LRZ 7LS0 7MZW 7MZY 7N00 7NWZ 7NX3 7NX4 7R7K 7R7R 8ARJ 9G5I 9GBE	5ZQZ 5ZRV 6DV2
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Phosphotyrosine Residue Binding Regulation Of Programmed Cell Death Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Insulin Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Negative Regulation Of Apoptotic Process ERBB Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Development Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Cell Adhesion Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Hemopoiesis Negative Regulation Of T Cell Differentiation Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Positive Regulation Of Biosynthetic Process Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of T Cell Activation Receptor Tyrosine Kinase Binding Leukocyte Activation Positive Regulation Of Gliogenesis Intracellular Signal Transduction Positive Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Glial Cell Differentiation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Immune System Process Leukocyte Activation Involved In Immune Response Negative Regulation Of Leukocyte Cell-cell Adhesion Cell Activation Involved In Immune Response Cellular Response To Growth Factor Stimulus Regulation Of Immune System Process Negative Regulation Of Lymphocyte Activation Lymphocyte Activation Cell Activation Response To Growth Factor Negative Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Development Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Leukocyte Activation Insulin-like Growth Factor Receptor Signaling Pathway	Mitochondrial Intermembrane Space
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?