RHBDD2 and SYT16

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RHBDD2	SYT16
Description		rhomboid domain containing 2	synaptotagmin 16
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Activity Signal Recognition Particle Binding Protein Binding	Protein Binding Phospholipid Binding Identical Protein Binding
	Biological Process	Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway
Pathways
Drugs
Diseases
GWAS		Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Sum eosinophil basophil counts ( 27863252)	Adult body size ( 32376654) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Chronotype ( 30696823) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136) Hepatitis ( 25705159) Longevity (90 years and older) ( 24688116) Recurrence of mild malaria attacks ( 31667592) Self-rated health ( 20707712) Telomere length ( 24478790)
Interacting Genes		60 interacting genes: ABHD16A ACSF2 ADORA2A BCL2L1 BCL2L2 CCR9 CHRM4 CIAO2A CIDEB COL8A1 COMT DIABLO DRD2 DYNC1H1 ERBB2 FKBP8 FMO4 GAL3ST3 GCSH GDF5-AS1 H2BC3 H4C7 IFI27L1 IL32 LETMD1 LIG4 MAOB MICOS13 MIEF2 MLX MMRN2 MPC2 MRM1 MRPL35 MTERF3 MYG1 NAALAD2 NCBP2AS2 NEDD4 NFU1 NRM PBX3 PTAFR ROMO1 RSAD2 SCGB3A1 SDHD SLC25A2 SLC25A3 SLC71A3P SNPH SYT16 TEX44 THBD TIMM17B TPRG1 TSR1 TUFM USP30 YAP1	29 interacting genes: AGTRAP APOC1 APOC2 APOC4 C10orf67 CMTM5 CYSTM1 DERL3 FGF14 GSG1 HIGD1C LDAF1 MPC2 MTFR1 NCOA5 PHC2 PLEKHF2 RABAC1 REEP6 RER1 RHBDD2 RPRM RTN4 SDR16C5 SFT2D1 SYT14 TMEM239 TVP23B ZBTB14
Entrez ID		57414	83851
HPRD ID		11492	15461
Ensembl ID		ENSG00000005486	ENSG00000139973
Uniprot IDs		Q6NTF9	Q17RD7
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Synaptic Transmission, Dopaminergic Mitochondrial Envelope Mitochondrion Organization Apoptotic Signaling Pathway Response To Amphetamine Dopamine Metabolic Process Response To Alkaloid Regulation Of Catecholamine Secretion Protein Binding Response To Amine Membrane Epithelial Cell Proliferation Mitochondrial Membrane Bcl-2 Family Protein Complex Intrinsic Apoptotic Signaling Pathway Mitochondrial Matrix Catecholamine Catabolic Process Catecholamine Metabolic Process Dopamine Catabolic Process Protein Localization To Mitochondrion	High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Acylglycerol Homeostasis Triglyceride Homeostasis Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Signal Recognition Particle Binding Endoplasmic Reticulum Lipid Homeostasis Chylomicron Phospholipid Efflux Endoplasmic Reticulum Membrane Negative Regulation Of Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport Plasma Lipoprotein Particle Clearance Lipoprotein Metabolic Process Regulation Of Phospholipid Metabolic Process Cholesterol Efflux Plasma Lipoprotein Particle Remodeling Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Phosphatidylcholine Catabolic Process Membrane Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Protein-containing Complex Remodeling Negative Regulation Of Lipid Transport Regulation Of Triglyceride Metabolic Process
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