GJD2 and PAK6

		GJD2	PAK6
Description		gap junction protein delta 2	p21 (RAC1) activated kinase 6
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GO Annotations	Cellular Component	Plasma Membrane Gap Junction Connexin Complex Membrane Synapse Anchoring Junction	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Cell Junction
	Molecular Function	Gap Junction Channel Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cadherin Binding Protein Serine Kinase Activity
	Biological Process	Cell Communication Cell-cell Signaling Chemical Synaptic Transmission Visual Perception Neuronal Action Potential Transmembrane Transport	Regulation Of DNA-templated Transcription Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Cellular Response To Starvation Intracellular Signal Transduction Regulation Of MAPK Cascade Neuron Projection Arborization Neuron Projection Extension
Pathways		Electric Transmission Across Gap Junctions Gap junction assembly	Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle RHOV GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Axial length ( 24144296 25823570) Congenital left-sided heart lesions ( 25138779) High myopia ( 31816047 32428537 33830181) Hyperopia ( 25233373) Low myopia vs hyperopia ( 33830181) Myopia ( 25233373 27182965) Refractive error ( 20835239 23396134 32231278) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)
Interacting Genes		3 interacting genes: LNX1 LNX2 PAK6	27 interacting genes: APP AR CACNA1H CDC42 CDIN1 CDK1 DAPK1 DLL4 ESR1 FBXO7 GJD2 HSF2BP KNL1 LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RHOJ RHOV SEMA3B SNX2 SP3 SPG11 SUMO2 TPD52L1
Entrez ID		57369	56924
HPRD ID		09521	06426
Ensembl ID		ENSG00000159248	ENSG00000137843
Uniprot IDs		Q9UKL4	Q9NQU5
PDB IDs		2N6A 7XKI 7XKK 7XKT 7XL8 7XNH 7XNV 8HKP 8IYG 8QOJ 8R7P 8R7Q 8R7R 8XGD 8XGE 8XGF 8XGG 8XGJ 8XH8 8XH9	2C30 2ODB 4KS7 4KS8 6QDR 6QDS
Enriched GO Terms of Interacting Partners?		PDZ Domain Binding Ubiquitin-protein Transferase Activity	Intracellular Signal Transduction Anatomical Structure Morphogenesis Developmental Process Cellular Response To Estrogen Stimulus Protein Kinase Binding Supramolecular Fiber Organization Regulation Of Mitotic Cell Cycle Protein-containing Complex Protein Serine Kinase Activity Glutamatergic Synapse Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Cell Communication Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Developmental Growth Involved In Morphogenesis Regulation Of Developmental Process Regulation Of Developmental Growth Regulation Of Intracellular Signal Transduction Estrogen Response Element Binding Prostate Gland Growth Response To Estrogen Mitotic Nuclear Membrane Disassembly Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Cycle Process Protein Kinase Activity Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Cycle Cellular Developmental Process Regulation Of Locomotion Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Kinetochore Regulation Of Reproductive Process Positive Regulation Of Cell Migration Developmental Growth Regulation Of Growth Regulation Of MiRNA Transcription Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Reproductive Process Membrane Disassembly Nuclear Membrane Disassembly Leukocyte Differentiation GTP Binding Cell-cell Signaling Cellular Response To Oxygen-containing Compound Regulation Of Apoptotic Signaling Pathway
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