PAK6 and CACNA1H

		PAK6	CACNA1H
Description		p21 (RAC1) activated kinase 6	calcium voltage-gated channel subunit alpha1 H
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Cell Junction	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cadherin Binding Protein Serine Kinase Activity	Monoatomic Ion Channel Activity Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Low Voltage-gated Calcium Channel Activity Metal Ion Binding Scaffold Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Cellular Response To Starvation Intracellular Signal Transduction Regulation Of MAPK Cascade Neuron Projection Arborization Neuron Projection Extension	Monoatomic Ion Transport Calcium Ion Transport Muscle Contraction Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Monoatomic Ion Transmembrane Transport Cortisol Biosynthetic Process Cellular Response To Potassium Ion Regulation Of Membrane Potential Transmembrane Transport Calcium Ion Import Calcium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Calcium Ion Import Across Plasma Membrane Positive Regulation Of Acrosome Reaction
Pathways		Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle RHOV GTPase cycle	NCAM1 interactions Smooth Muscle Contraction Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs		Fostamatinib	Ergocalciferol Enflurane Isradipine Spironolactone Cinnarizine Nicardipine Nicardipine Verapamil Verapamil Zonisamide Felodipine Nitrendipine Nifedipine Bepridil Mibefradil Flunarizine Nilvadipine Nilvadipine Cannabidiol Trimebutine Barnidipine Aranidipine Benidipine Efonidipine Efonidipine Efonidipine Manidipine Manidipine Butamben Bioallethrin Bioallethrin Medical Cannabis Nabiximols
Diseases
GWAS		Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)	Eosinophil count ( 32888494) Leukocyte telomere length ( 32109421) Mastocytosis (KIT D816V positive) ( 33421400)
Interacting Genes		27 interacting genes: APP AR CACNA1H CDC42 CDIN1 CDK1 DAPK1 DLL4 ESR1 FBXO7 GJD2 HSF2BP KNL1 LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RHOJ RHOV SEMA3B SNX2 SP3 SPG11 SUMO2 TPD52L1	4 interacting genes: CCR4 GNG2 KCNMA1 PAK6
Entrez ID		56924	8912
HPRD ID		06426	07442
Ensembl ID		ENSG00000137843	ENSG00000196557
Uniprot IDs		Q9NQU5	A0A1W2PQW2 A0AAA9YHH8 B3KQH9 H3BMW6 H3BNT0 H3BUA8 O95180
PDB IDs		2C30 2ODB 4KS7 4KS8 6QDR 6QDS	9AYG 9AYH 9AYJ 9AYK 9AYL
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Anatomical Structure Morphogenesis Developmental Process Cellular Response To Estrogen Stimulus Protein Kinase Binding Supramolecular Fiber Organization Regulation Of Mitotic Cell Cycle Protein-containing Complex Protein Serine Kinase Activity Glutamatergic Synapse Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Cell Communication Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Developmental Growth Involved In Morphogenesis Regulation Of Developmental Process Regulation Of Developmental Growth Regulation Of Intracellular Signal Transduction Estrogen Response Element Binding Prostate Gland Growth Response To Estrogen Mitotic Nuclear Membrane Disassembly Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Cycle Process Protein Kinase Activity Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Cycle Cellular Developmental Process Regulation Of Locomotion Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Kinetochore Regulation Of Reproductive Process Positive Regulation Of Cell Migration Developmental Growth Regulation Of Growth Regulation Of MiRNA Transcription Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Reproductive Process Membrane Disassembly Nuclear Membrane Disassembly Leukocyte Differentiation GTP Binding Cell-cell Signaling Cellular Response To Oxygen-containing Compound Regulation Of Apoptotic Signaling Pathway	Large Conductance Calcium-activated Potassium Channel Activity Response To Carbon Monoxide Smooth Muscle Contraction Involved In Micturition Micturition Chemokine Receptor Activity Interneuron Migration C-C Chemokine Binding C-C Chemokine Receptor Activity Tolerance Induction Calcium-activated Potassium Channel Activity Negative Regulation Of Cell Volume Urinary Bladder Smooth Muscle Contraction Intracellular Potassium Ion Homeostasis Cellular Response To Catecholamine Stimulus Cellular Response To Prostaglandin E Stimulus Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Response To Catecholamine G Protein-coupled Dopamine Receptor Signaling Pathway G-protein Beta-subunit Binding Neuron Projection Arborization
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