COQ8A and DTX2

Number of citations of the paper that reports this interaction (PubMedID 25910212)
47

Data Source:
BioGRID (two hybrid)

		COQ8A	DTX2
Description		coenzyme Q8A	deltex E3 ubiquitin ligase 2
Image
GO Annotations	Cellular Component	Mitochondrion Membrane Extrinsic Component Of Mitochondrial Inner Membrane Mitochondrial Membrane	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Kinase Activity Transferase Activity ADP Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Phosphorylation Ubiquinone Biosynthetic Process Phosphorylation	Notch Signaling Pathway Protein Ubiquitination
Pathways		Ubiquinol biosynthesis	Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus
Drugs		Fostamatinib
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Coenzyme Q10 deficiency
GWAS
Interacting Genes		27 interacting genes: ABHD5 AGTRAP CCDC34 CMTM4 CMTM5 CMTM6 COQ9 DESI2 DTX2 JOSD2 LDAF1 MAL2 MRM1 MTIF3 ORMDL3 PBX3 RABAC1 REEP6 RPRM SH3GLB1 SMPD2 STX10 TFIP11 TMCO2 TMEM239 TPD52L2 UBC	135 interacting genes: ABHD11 ABHD16A ACTMAP ALKBH4 ANAPC11 ANTKMT ARID5A ARMC7 ARNT2 BCL2L11 BICRAL BOLA2-SMG1P6 C10orf55 C1orf94 C22orf39 CCDC57 CFAP68 CIMIP1 CLPP COA6 COQ8A DAZAP2 DOK3 DTX1 DTX3 ECM1 ECSIT EIF4ENIF1 EIF4G1 EYA2 FAM168A FCRL4 FHL2 FHL5 FOXI1 FTO GLYCTK GOLGA2 H3C1 HDC HGS HLX HOXA1 HOXB2 HOXD12 HPCA HPCAL1 HPCAL4 HSFY1 HSFY2 IKZF3 KANK2 KLC3 KLHDC7B KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP26-1 KRTAP6-1 KRTAP7-1 KRTAP8-1 LASP1 LNX1 LRP2BP MBD3L1 MDC1 MED19 MSS51 MVP MXRA8 NCALD NCS1 NHLRC4 NIF3L1 NME4 NOTCH1 OIP5 PARP1 PARP10 PAX5 PLEKHF2 PLEKHG4 PLSCR1 POGZ PRR32 PRR34 PSMB4 QARS1 RBM11 RBPMS RFX6 RHOXF2 RIMBP3 RUNX1 RUNX2 RUNX3 RUSC1 SAXO4 SEC22A SEC23A SEC23B SEPSECS SLC67A1-AS SOHLH1 SPAG8 STX12 SUMO1 TBX15 TEKT5 TENT2 TMEM42 TRIB3 TRIM35 TRIM54 TRIP13 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBQLN4 USP54 VGLL3 VSNL1 ZNF34 ZNF503 ZNF620 ZNF641 ZNF764 ZNF774 ZNF85
Entrez ID		56997	113878
HPRD ID		07375	16841
Ensembl ID		ENSG00000163050	ENSG00000091073
Uniprot IDs		Q8NI60	Q86UW9
PDB IDs		4PED 5I35 7UDP 7UDQ	6IR0 6Y22 6Y2X 6Y3J
Enriched GO Terms of Interacting Partners?			Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Axonemal A Tubule Inner Sheath Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Ubiquitin Conjugating Enzyme Activity Nucleus Core-binding Factor Complex Apoptotic Process Involved In Embryonic Digit Morphogenesis Chromatin Regulation Of Base-excision Repair Broad Specificity Oxidative DNA Demethylase Activity
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