NMUR2 and ADAMTSL4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		NMUR2	ADAMTSL4
Description		neuromedin U receptor 2	ADAMTS like 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Interstitial Matrix Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Neuromedin U Receptor Activity G Protein-coupled Receptor Activity Intracellularly Calcium-gated Chloride Channel Activity Protein Binding GTP Binding Neuropeptide Receptor Activity Neuromedin U Binding	Protease Binding Protein Binding Identical Protein Binding
	Biological Process	Reduction Of Food Intake In Response To Dietary Excess Chloride Transport Regulation Of Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Central Nervous System Development Grooming Behavior Feeding Behavior Response To Pain Arachidonate Secretion Positive Regulation Of Calcium-mediated Signaling Chloride Transmembrane Transport	Epithelial Cell Development Apoptotic Process Extracellular Matrix Organization Positive Regulation Of Apoptotic Process Pigment Cell Development
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs
Diseases			Ectopia lentis
GWAS		Ability to confide in someone ( 29970889) Adult body size ( 32376654) Bipolar disorder ( 33169155) Bipolar disorder and schizophrenia ( 22688191) Body size at age 10 ( 32376654) Caffeine consumption from tea ( 33287642) Chronotype ( 30696823) Feeling lonely ( 29500382) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Manganese levels ( 26025379) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Optic nerve measurement (cup area) ( 20395239) Periodontitis (PAL4Q3) ( 24024966) Schizophrenia ( 28991256) Sedentary behaviour duration ( 30531941) Subjective well-being ( 27089181)	Appendicular lean mass ( 33097823) Asthma ( 32296059) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Migraine ( 27322543) Refractive error ( 32231278) Rhegmatogenous retinal detachment ( 23585552) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		6 interacting genes: ADAMTSL4 KRTAP13-1 NMU NOTCH2NLA TCF4 TRAF2	213 interacting genes: ADAM12 ADAMTSL5 ALPP AMMECR1 APOL6 AQP1 ARNT2 ASPSCR1 ATG9A BAG4 BANF2 BOLA2 BOLA2B BRME1 CATSPER1 CBX3 CCDC26 CFAP206 CHCHD2 CHERP CHIC2 CHRD CHRNG CLEC18A COL8A1 CPNE7 CREB5 CST2 CTSB CXCL16 CYP2S1 CYSRT1 DGCR6 DGCR6L DIP2A DLK2 DNPEP DSCR8 EFEMP2 EIF4E2 EPDR1 ERCC3 EXOSC5 FAH FAM124B FARS2 FBLN1 FBXL9P FBXO17 FBXW5 FHL3 FKBP1B FLNA FRS3 FXR1 GATA2 GIP GLRX3 GLYCTK GMCL2 GNE GNG13 GNMT GOLGA8EP GSTP1 GUCD1 HEXIM2 HGF HNRNPLL HOXA1 HOXC8 HSD3B7 INS IP6K1 ITGB2 ITGB4 JOSD1 KCTD7 KCTD9 KIF1A KLHL38 KRTAP1-1 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP19-2 KRTAP21-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LGALS14 LHX4 LINC00671 LMO1 LMO2 LMO4 LNX1 LONRF1 LRFN4 MAGOHB MAPKBP1 MGAT5B MID2 MKRN3 MORN3 MVP MYLIP MYO15B NATD1 NBPF19 NEK8 NFKBID NMUR2 NOTCH2NLA NR4A3 NTAQ1 NTF4 NTN4 NUFIP2 OLFM3 OTX1 PCSK5 PID1 PIN1 PKN1 PLEKHO1 PLSCR1 PLSCR4 POLD1 POLR1C POU4F2 PRKAB2 PRR19 PTGER3 PTPMT1 QPRT R3HDM2 RAB2B RCHY1 RGL2 RHOJ RPS19BP1 RUNX1T1 SALL2 SCNM1 SHFL SLC13A5 SLC23A1 SLC6A20 SLIT1 SMARCC1 SORBS3 SPATA8 SPINK2 SPRY1 SPRY2 STK16 SUSD6 TAPBPL TCEA2 TFAP2D TGFB1 THAP6 TMEM150A TMSB4XP6 TOP3B TRIM42 TRIM55 TRIM63 TRIP6 TSSK3 TUBGCP4 USP21 VASN VENTX VWC2 ZFHX2 ZNF330 ZNF414 ZNF417 ZNF587
Entrez ID		56923	54507
HPRD ID		12003	18237
Ensembl ID		ENSG00000132911	ENSG00000143382
Uniprot IDs		Q9GZQ4	A0A669KBE7 B7ZMJ3 Q6UY14
PDB IDs		7W55 7W57 7XK8
Enriched GO Terms of Interacting Partners?		TORC2 Complex Disassembly Neuromedin U Receptor Binding Type 2 Neuromedin U Receptor Binding Negative Regulation Of Gastric Emptying Positive Regulation Of Stomach Fundus Smooth Muscle Contraction Type 1 Neuromedin U Receptor Binding Pigment Cell Development TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Positive Regulation Of Prolactin Secretion TFIIB-class Transcription Factor Binding Beta-catenin-TCF7L2 Complex Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Negative Regulation Of Gastric Acid Secretion Positive Regulation Of Sensory Perception Of Pain Regulation Of Gastric Motility Regulation Of Grooming Behavior Negative Regulation Of Eating Behavior CD27 Signaling Pathway Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Regulation Of Gastric Acid Secretion Negative Regulation Of Feeding Behavior Interstitial Matrix Regulation Of Eating Behavior Gastric Acid Secretion Thioesterase Binding CD40 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Interleukin-17-mediated Signaling Pathway CD40 Receptor Complex Positive Regulation Of Heat Generation Positive Regulation Of JUN Kinase Activity Beta-catenin-TCF Complex TORC2 Signaling Cellular Response To Nitric Oxide Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Mitogen-activated Protein Kinase Kinase Kinase Binding Positive Regulation Of Systemic Arterial Blood Pressure Cellular Response To Reactive Nitrogen Species	Intermediate Filament Keratinization Keratin Filament Epidermis Development Protein Binding Tissue Development Identical Protein Binding Hair Cycle
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