AKIP1 and QSOX1

		AKIP1	QSOX1
Description		A-kinase interacting protein 1	quiescin sulfhydryl oxidase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Membrane Platelet Alpha Granule Lumen Specific Granule Lumen Extracellular Exosome Tertiary Granule Lumen
	Molecular Function	Protein Binding	Protein Disulfide Isomerase Activity Oxidoreductase Activity Flavin-dependent Sulfhydryl Oxidase Activity Thiol Oxidase Activity FAD Binding
	Biological Process	Substrate Adhesion-dependent Cell Spreading Regulation Of Non-canonical NF-kappaB Signal Transduction	Protein Folding Negative Regulation Of Macroautophagy Extracellular Matrix Assembly
Pathways			Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain morphology (MOSTest) ( 32665545) Hemoglobin levels ( 32327693)	Anorexia nervosa ( 23568457) Pulse pressure ( 30224653 30578418)
Interacting Genes		8 interacting genes: BARD1 FHL2 HMGB1 MAPK13 MCPH1 PRKACA QSOX1 SPTAN1	16 interacting genes: AKIP1 BEGAIN CCR1 CCR6 CHRM4 CREG1 GPR52 GREM2 KIF5B PHAF1 PRRX1 SERPINC1 SHANK3 TNR UBE2D2 UBQLN4
Entrez ID		56672	5768
HPRD ID		12380	06785
Ensembl ID		ENSG00000166452	ENSG00000116260
Uniprot IDs		Q9NQ31	A0A140VKE5 O00391
PDB IDs			3LLI 3LLK 3Q6O 4IJ3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone H2AK127 Ubiquitin Ligase Activity Regulation Of Protein Export From Nucleus Negative Regulation Of Metabolic Process Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of MRNA 3'-end Processing BRCA1-BARD1 Complex Atrial Cardiac Muscle Cell Development Regulation Of Calcium-mediated Signaling Positive Regulation Of Glucose Metabolic Process Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Interleukin-6 Production Regulation Of Glucose Metabolic Process Regulation Of Autophagy Positive Regulation Of Myeloid Progenitor Cell Differentiation Negative Regulation Of Apoptotic Cell Clearance Cellular Response To Carbohydrate Stimulus Cellular Response To Sorbitol Specific Granule Lumen Tertiary Granule Lumen Regulation Of Phagocytosis BRCA1-B Complex Regulation Of Nucleocytoplasmic Transport Regulation Of Mismatch Repair C-X-C Chemokine Binding Negative Regulation Of Protein-containing Complex Assembly Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Positive Regulation Of Mismatch Repair Plasmacytoid Dendritic Cell Activation Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Response To Anisomycin Cellular Response To Anisomycin Response To Sorbitol Flavin-dependent Sulfhydryl Oxidase Activity Regulation Of Intracellular Protein Transport Negative Regulation Of RNA Metabolic Process Nuclear Ubiquitin Ligase Complex BRCA1-C Complex Cellular Response To Radiation Negative Regulation Of Macromolecule Metabolic Process Response To Hormone Negative Regulation Of DNA-templated Transcription Initiation	G Protein-coupled Receptor Activity Chemokine Receptor Activity Dendritic Cell Migration Dendritic Cell Chemotaxis C-C Chemokine Binding C-C Chemokine Receptor Activity Positive Regulation Of Synaptic Transmission Regulation Of Neuron Projection Regeneration Positive Regulation Of Synaptic Transmission, Glutamatergic
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