EIF5A2 and NIF3L1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		EIF5A2	NIF3L1
Description		eukaryotic translation initiation factor 5A2	NGG1 interacting factor 3 like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane	Nucleus Cytoplasm Mitochondrion
	Molecular Function	RNA Binding Translation Elongation Factor Activity Protein Binding Ribosome Binding	Protein Binding Identical Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Translation Translational Elongation Spermatogenesis Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Neuron Differentiation Positive Regulation Of DNA-templated Transcription
Pathways		Hypusine synthesis from eIF5A-lysine
Drugs
Diseases
GWAS		C-reactive protein levels ( 30388399) Urate levels ( 31578528)	Triptolide cytotoxicity ( 26121980)
Interacting Genes		10 interacting genes: CDC23 DHPS FNDC3B HERC3 HIF1A NIF3L1 PTBP2 RAB30 REL SDCBP	100 interacting genes: ABI2 ALKBH4 AP5B1 APIP ARPIN BDKRB2 BEND7 C14orf119 CASP7 CCDC102B CCDC85B CDKN2B CDKN2C CDKN2D COIL COPS2 CUTC CXCL12 CYRIB DCDC2 DCTD DCTPP1 DHPS DMC1 DMRTB1 DTX2 DUSP23 DUSP29 DYNLT3 EIF4A3 EIF5A2 ENOX1 EPHB6 FLAD1 FXR2 GNMT GRB2 ICOS IP6K3 KCNIP1 KCTD17 KCTD7 KCTD9 KLRC2 KRT15 KXD1 LAMTOR3 LMO2 LMO3 MAGEA11 MAPRE2 MLXIPL NATD1 NEK6 NGB NME1 NME7 NOL3 NUDT14 NUDT21 ORC5 PAFAH1B3 PAICS PCBD1 PNMA1 POLR1C PPIH PRTFDC1 PTPA RABAC1 RAD54B RAPH1 RGMB RPIA S100A1 SAT1 SEPTIN1 SNF8 SPG21 SSX2IP STAT3 STK16 SULT1A2 SULT1A3 SULT2A1 SYT17 TCL1A THOC7 TIFA TRAF2 TRAK2 TRIM21 TRIM27 TRIP13 TSC22D4 TXN VIM YES1 YWHAQ ZBED1
Entrez ID		56648	60491
HPRD ID		10426	10424
Ensembl ID		ENSG00000163577	ENSG00000196290
Uniprot IDs		Q9GZV4	Q9GZT8
PDB IDs
Enriched GO Terms of Interacting Partners?			Identical Protein Binding Cytoplasm Protein Binding Cytosol Protein Complex Oligomerization Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Ethanol Catabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Ethanol Metabolic Process Nucleoside Phosphate Metabolic Process Phosphate-containing Compound Metabolic Process Sulfation Pyrimidine Nucleotide Metabolic Process Polyamine Catabolic Process Nucleus Ribose Phosphate Metabolic Process Reciprocal Meiotic Recombination
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