PSAP and NLGN3

Number of citations of the paper that reports this interaction (PubMedID 25464930)
0

Data Source:
BioGRID (two hybrid)

		PSAP	NLGN3
Description		prosaposin	neuroligin 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Azurophil Granule Membrane Lysosomal Lumen Extracellular Exosome	Plasma Membrane Cell Surface Membrane Endocytic Vesicle Synapse Postsynaptic Membrane Excitatory Synapse Presynapse Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Asymmetric, Glutamatergic, Excitatory Synapse
	Molecular Function	Protease Binding Protein Binding Phospholipid Binding Enzyme Activator Activity Lipid Binding Identical Protein Binding Protein Homodimerization Activity Scaffold Protein Binding Ganglioside GM1 Binding Ganglioside GM2 Binding Ganglioside GM3 Binding Ganglioside GT1b Binding Ganglioside GP1c Binding	Protein Binding Signaling Receptor Activity Neurexin Family Protein Binding Cell Adhesion Molecule Binding Scaffold Protein Binding
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Lysosomal Transport Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Autophagy Regulation Of Lipid Metabolic Process Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of Beta-galactosidase Activity Ganglioside GM1 Transport To Membrane	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Receptor-mediated Endocytosis Cell Adhesion Neuron Cell-cell Adhesion Chemical Synaptic Transmission Synapse Assembly Learning Adult Behavior Social Behavior Synaptic Vesicle Endocytosis Axon Extension Modulation Of Chemical Synaptic Transmission Synapse Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Rhythmic Synaptic Transmission Inhibitory Postsynaptic Potential Vocalization Behavior Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynapse Assembly Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Platelet degranulation Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Glycosphingolipid catabolism	Neurexins and neuroligins Neurexins and neuroligins
Drugs		Di-Stearoyl-3-Sn-Phosphatidylethanolamine
Diseases		Krabbe disease; Globoid cell leukodystrophy Gaucher disease Metachromatic leukodystrophy (MLD)
GWAS		Asthma (childhood onset) ( 23829686) Seasonality and depression ( 30217971)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Prostate cancer ( 25217961)
Interacting Genes		23 interacting genes: APPBP2 BACE1 BRCA1 CD1B CELSR1 COPS6 CPEB2 CTSD DYRK1A ERBB2 GBA1 HSPA13 MAFF NLGN3 PEX5 PRAG1 SGCG SMAD2 SMAD9 TOMM70 UBE3A USP4 ZBED1	66 interacting genes: AKT1 ALPP AP2A2 APC2 ATF4 ATXN1 C1orf122 C1QA CCAR2 CGB3 COBL CTSD DLG2 DLG3 DLG4 DPEP2 EBPL EFEMP1 EFS FANCG FBLN1 FHOD1 FKBP1A FLNA GDF15 GUK1 HID1 HIVEP1 ITPRIP LGALS1 MAN2C1 MAP1S MEOX2 MIEN1 NFATC4 NRDC NRXN1 NRXN2 NRXN3 OAZ1 OR1F12P PDZD11 PICK1 PKIB PLB1 PLCB4 PRDX2 PSAP PSG1 PSG11 PSG3 PSG4 PSG5 QARS1 RBFOX2 SPAG5 SPINT1 SSR4 TDRD7 TLE5 TNNT3 TRIM33 TXNIP UBQLN1 UBXN6 UQCRC1
Entrez ID		5660	54413
HPRD ID		01460	02275
Ensembl ID		ENSG00000197746	ENSG00000196338
Uniprot IDs		P07602	A0A8I5KSB7 A0A8I5QJH8 B7Z3P8 Q4G160 Q9NZ94 X5D2P6 X5D7L6 X5DNV3
PDB IDs		1M12 1N69 1SN6 2DOB 2GTG 2QYP 2R0R 2R1Q 2RB3 2Z9A 3BQP 3BQQ 4DDJ 4UEX 4V2O 6SLR 8EQU 9AVS 9AXG	8GS3
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process Protein Metabolic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Post-translational Protein Modification Protein Modification Process I-SMAD Binding Protein Modification By Small Protein Conjugation Antigen Processing And Presentation Aspartic-type Endopeptidase Activity Lysosome Response To Thyroid Hormone Transcription Coactivator Activity Endosome Membrane SMAD Protein Signal Transduction Receptor Recycling Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Protein-containing Complex Assembly	Receptor Clustering Neuroligin Family Protein Binding Kinase Binding Protein Localization To Cell Junction Vocalization Behavior Social Behavior Protein Localization To Synapse Female Pregnancy Protein Localization To Membrane Cell-cell Adhesion Neuron Cell-cell Adhesion Receptor Localization To Synapse Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Cellular Response To Metal Ion Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway GDF15-GFRAL Signaling Pathway Somite Specification Gephyrin Clustering Involved In Postsynaptic Density Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Localization Within Membrane Ionotropic Glutamate Receptor Binding NMDA Selective Glutamate Receptor Signaling Pathway Trans-synaptic Protein Complex Postsynaptic Density Protein 95 Clustering Negative Regulation Of Signal Transduction Neuromuscular Junction Postsynapse Response To Metal Ion Negative Regulation Of Apoptotic Signaling Pathway Postsynaptic Membrane Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Learning Vocal Learning Cell Adhesion Cell-cell Signaling GMP Kinase Activity Postsynaptic Membrane Organization Neurotransmitter Secretion Observational Learning Cellular Localization Learning Or Memory Protein Kinase Inhibitor Activity Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signaling Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway PERK-mediated Unfolded Protein Response GDP Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?