NLGN3 and GUK1

Number of citations of the paper that reports this interaction (PubMedID 25464930)
0

Data Source:
BioGRID (two hybrid)

		NLGN3	GUK1
Description		neuroligin 3	guanylate kinase 1
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Endocytic Vesicle Synapse Postsynaptic Membrane Excitatory Synapse Presynapse Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Asymmetric, Glutamatergic, Excitatory Synapse	Photoreceptor Inner Segment Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding Signaling Receptor Activity Neurexin Family Protein Binding Cell Adhesion Molecule Binding Scaffold Protein Binding	Nucleotide Binding GMP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Receptor-mediated Endocytosis Cell Adhesion Neuron Cell-cell Adhesion Chemical Synaptic Transmission Synapse Assembly Learning Adult Behavior Social Behavior Synaptic Vesicle Endocytosis Axon Extension Modulation Of Chemical Synaptic Transmission Synapse Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Rhythmic Synaptic Transmission Inhibitory Postsynaptic Potential Vocalization Behavior Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynapse Assembly Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential	Purine Nucleotide Metabolic Process DGDP Biosynthetic Process Xenobiotic Metabolic Process Nucleobase-containing Small Molecule Interconversion GDP-mannose Metabolic Process Glycoprotein Transport GMP Metabolic Process DGMP Metabolic Process DATP Metabolic Process GDP Biosynthetic Process
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Interconversion of nucleotide di- and triphosphates Azathioprine ADME
Drugs			Guanosine-5'-Monophosphate
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Prostate cancer ( 25217961)	Coronary artery disease ( 29212778)
Interacting Genes		66 interacting genes: AKT1 ALPP AP2A2 APC2 ATF4 ATXN1 C1orf122 C1QA CCAR2 CGB3 COBL CTSD DLG2 DLG3 DLG4 DPEP2 EBPL EFEMP1 EFS FANCG FBLN1 FHOD1 FKBP1A FLNA GDF15 GUK1 HID1 HIVEP1 ITPRIP LGALS1 MAN2C1 MAP1S MEOX2 MIEN1 NFATC4 NRDC NRXN1 NRXN2 NRXN3 OAZ1 OR1F12P PDZD11 PICK1 PKIB PLB1 PLCB4 PRDX2 PSAP PSG1 PSG11 PSG3 PSG4 PSG5 QARS1 RBFOX2 SPAG5 SPINT1 SSR4 TDRD7 TLE5 TNNT3 TRIM33 TXNIP UBQLN1 UBXN6 UQCRC1	5 interacting genes: HNRNPD LCOR NLGN3 STAG1 VHL
Entrez ID		54413	2987
HPRD ID		02275	00755
Ensembl ID		ENSG00000196338	ENSG00000143774
Uniprot IDs		A0A8I5KSB7 A0A8I5QJH8 B7Z3P8 Q4G160 Q9NZ94 X5D2P6 X5D7L6 X5DNV3	Q16774 Q6IBG8
PDB IDs		8GS3	6NUI 8PTS
Enriched GO Terms of Interacting Partners?		Receptor Clustering Neuroligin Family Protein Binding Kinase Binding Protein Localization To Cell Junction Vocalization Behavior Social Behavior Protein Localization To Synapse Female Pregnancy Protein Localization To Membrane Cell-cell Adhesion Neuron Cell-cell Adhesion Receptor Localization To Synapse Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Cellular Response To Metal Ion Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway GDF15-GFRAL Signaling Pathway Somite Specification Gephyrin Clustering Involved In Postsynaptic Density Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Localization Within Membrane Ionotropic Glutamate Receptor Binding NMDA Selective Glutamate Receptor Signaling Pathway Trans-synaptic Protein Complex Postsynaptic Density Protein 95 Clustering Negative Regulation Of Signal Transduction Neuromuscular Junction Postsynapse Response To Metal Ion Negative Regulation Of Apoptotic Signaling Pathway Postsynaptic Membrane Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Learning Vocal Learning Cell Adhesion Cell-cell Signaling GMP Kinase Activity Postsynaptic Membrane Organization Neurotransmitter Secretion Observational Learning Cellular Localization Learning Or Memory Protein Kinase Inhibitor Activity Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signaling Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway PERK-mediated Unfolded Protein Response GDP Metabolic Process	Cellular Response To Estradiol Stimulus Hepatocyte Dedifferentiation Cellular Response To Putrescine Response To Estradiol Histone Deacetylase Binding Circadian Regulation Of Translation Rhythmic Synaptic Transmission Symmetric, GABA-ergic, Inhibitory Synapse Response To Rapamycin Positive Regulation Of Telomere Capping Cell Dedifferentiation MCRD-mediated MRNA Stability Complex Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding Transcription Elongation Factor Activity Establishment Of Mitotic Sister Chromatid Cohesion Cohesin Complex Establishment Of Sister Chromatid Cohesion Mitotic Cohesin Complex Asymmetric, Glutamatergic, Excitatory Synapse Inhibitory Postsynaptic Potential Positive Regulation Of Glutamate Receptor Signaling Pathway Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Neuron To Neuron Synapse Presynaptic Membrane Organization CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of Glutamate Receptor Signaling Pathway Neurexin Family Protein Binding Presynapse Assembly Cellular Response To Nitric Oxide Negative Regulation Of Catabolic Process Regulation Of Telomere Capping Regulation Of Respiratory System Process Neuron Cell-cell Adhesion Histone Methyltransferase Binding Negative Regulation Of RNA Metabolic Process Cellular Response To Reactive Nitrogen Species Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cytoplasmic Translation 3'-UTR-mediated MRNA Destabilization Response To Nitric Oxide Response To Ether Regulation Of Cellular Response To Hypoxia Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
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