PRSS2 and DMBT1

		PRSS2	DMBT1
Description		serine protease 2	deleted in malignant brain tumors 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Azurophil Granule Lumen	Extracellular Region Extracellular Space Cytoplasm Membrane Phagocytic Vesicle Membrane Extracellular Matrix Zymogen Granule Membrane Extracellular Exosome
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding	Lipopolysaccharide Binding DNA Binding Scavenger Receptor Activity Protein Binding Zymogen Binding Pattern Recognition Receptor Activity Calcium-dependent Protein Binding Lipoteichoic Acid Binding Heparan Sulfate Binding
	Biological Process	Proteolysis Digestion Antimicrobial Humoral Response Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Collagen Catabolic Process Positive Regulation Of Cell Adhesion	Receptor-mediated Endocytosis Defense Response Protein Transport Vesicle-mediated Transport Cell Differentiation Epithelial Cell Differentiation Induction Of Bacterial Agglutination Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Virus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Collagen degradation Alpha-defensins Activation of Matrix Metalloproteinases Neutrophil degranulation Antimicrobial peptides	Surfactant metabolism
Drugs		Monoisopropylphosphorylserine O-Benzylsulfonyl-Serine Benzylamine Benzamidine Phosphorylisopropane Phenethylamine 3-Phenylpropylamine
Diseases		Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS		Pancreatitis ( 23143602)	Femur bone mineral density x serum urate levels interaction ( 34046847) Iris heterochromicity ( 30895295)
Interacting Genes		9 interacting genes: APP BPI CSN1S1 DMBT1 GLP1R MKKS MMP9 SERPINA1 SLPI	8 interacting genes: GNB3 MEAF6 MRPS6 PRSS2 SELENBP1 SFTPA1 SFTPD UBC
Entrez ID		5645	1755
HPRD ID		03335	03575
Ensembl ID		ENSG00000275896	ENSG00000187908
Uniprot IDs		A0A0J9YYC8 A6XMV9 P07478 Q5NV56 Q6PK75	A0A590UJ76 Q9UGM3
PDB IDs			6SA4 6SA5 6SAN 8J8D 8J8T 8WZS
Enriched GO Terms of Interacting Partners?		Antibacterial Humoral Response Extracellular Space Antimicrobial Humoral Response Humoral Immune Response Heparan Sulfate Binding Defense Response To Bacterium Serine-type Endopeptidase Inhibitor Activity Extracellular Region Defense Response To Gram-negative Bacterium Peptidase Inhibitor Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Response To Bacterium Extracellular Matrix Lipopolysaccharide Binding Extracellular Exosome Innate Immune Response Response To External Biotic Stimulus Negative Regulation Of Blood Pressure Defense Response Amyloid-beta Complex Growth Cone Lamellipodium Defense Response To Symbiont Regulation Of Response To Calcium Ion Platelet Alpha Granule Lumen Defense Response To Other Organism Regulation Of Multicellular Organism Growth Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Specific Granule Lumen Response To Lipopolysaccharide Response To Lipid Response To 11-deoxycorticosterone Zymogen Binding Glucagon-like Peptide 1 Receptor Activity Response To Molecule Of Bacterial Origin Cellular Response To Oxygen-containing Compound Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Pigment Granule Aggregation In Cell Center PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization	Respiratory Gaseous Exchange By Respiratory System Clathrin-coated Endocytic Vesicle Extracellular Space Multivesicular Body Collagen Trimer Methanethiol Oxidase Activity
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