DMBT1 and GNB3

		DMBT1	GNB3
Description		deleted in malignant brain tumors 1	G protein subunit beta 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Membrane Phagocytic Vesicle Membrane Extracellular Matrix Zymogen Granule Membrane Extracellular Exosome	Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Dendrite Cell Body Extracellular Exosome
	Molecular Function	Lipopolysaccharide Binding DNA Binding Scavenger Receptor Activity Protein Binding Zymogen Binding Pattern Recognition Receptor Activity Calcium-dependent Protein Binding Lipoteichoic Acid Binding Heparan Sulfate Binding	GTPase Activity Protein Binding Signaling Receptor Complex Adaptor Activity Spectrin Binding GTPase Binding
	Biological Process	Receptor-mediated Endocytosis Defense Response Protein Transport Vesicle-mediated Transport Cell Differentiation Epithelial Cell Differentiation Induction Of Bacterial Agglutination Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Virus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Cell Volume Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Regulation Of Hormone Metabolic Process Regulation Of Fat Cell Differentiation Regulation Of Feeding Behavior Regulation Of Cholesterol Metabolic Process Regulation Of Triglyceride Metabolic Process Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Phospholipid Metabolic Process
Pathways		Surfactant metabolism	Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production Sensory perception of sweet, bitter, and umami (glutamate) taste Sensory perception of sweet, bitter, and umami (glutamate) taste High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Iris heterochromicity ( 30895295)	Central retinal vein equivalent ( 26567291) High myopia ( 31816047 33830181) Macular thickness ( 30535121) Myopia ( 27182965) Refractive error ( 32231278) Response to Vitamin E supplementation ( 22437554) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		8 interacting genes: GNB3 MEAF6 MRPS6 PRSS2 SELENBP1 SFTPA1 SFTPD UBC	12 interacting genes: CIDEB DMBT1 GNG12 GNG13 GNG3 GNG4 GNG5 GNG7 GNG8 GRK2 RASD2 TGFBR1
Entrez ID		1755	2784
HPRD ID		03575	00743
Ensembl ID		ENSG00000187908	ENSG00000111664
Uniprot IDs		A0A590UJ76 Q9UGM3	E9PCP0 F1T0G5 P16520
PDB IDs		6SA4 6SA5 6SAN 8J8D 8J8T 8WZS
Enriched GO Terms of Interacting Partners?		Respiratory Gaseous Exchange By Respiratory System Clathrin-coated Endocytic Vesicle Extracellular Space Multivesicular Body Collagen Trimer Methanethiol Oxidase Activity	G-protein Beta-subunit Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Signaling Pathway Synapse Signal Transduction Membrane GTPase Activity Plasma Membrane Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Zymogen Binding Cellular Response To Pheromone Edg-2 Lysophosphatidic Acid Receptor Binding PDZ Domain Binding Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Response To Pheromone
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