SLC7A10 and TNFRSF9

		SLC7A10	TNFRSF9
Description		solute carrier family 7 member 10	TNF receptor superfamily member 9
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Protein Binding Organic Cation Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity L-serine Transmembrane Transporter Activity Transmembrane Transporter Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Amino Acid Transport Neutral Amino Acid Transport Glycine Transport L-serine Transport D-alanine Transmembrane Transport D-serine Transmembrane Transport Transmembrane Transport Positive Regulation Of Synaptic Transmission, Glycinergic L-alpha-amino Acid Transmembrane Transport Negative Regulation Of Brown Fat Cell Differentiation	Apoptotic Process Negative Regulation Of Cell Population Proliferation Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Cell Population Proliferation
Pathways		Basigin interactions Amino acid transport across the plasma membrane	TNFs bind their physiological receptors
Drugs			Urelumab
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Asthma ( 34103634 30929738 32296059 31959851 31361310 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Eosinophil count ( 32888494) Mastocytosis (KIT D816V positive) ( 33421400) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Multiple sclerosis ( 31604244) Red blood cell count ( 29403010) Triglyceride levels ( 32203549) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) White blood cell count (basophil) ( 29403010)	Blond vs. brown/black hair color ( 30531825) Celiac disease ( 20190752) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Psoriasis ( 23143594 25903422) Rheumatoid arthritis ( 24390342 30423114) Ulcerative colitis ( 21297633 28067908) Waist-hip ratio ( 28552196)
Interacting Genes		4 interacting genes: APPBP2 CFTR SLC3A2 TNFRSF9	13 interacting genes: AP1S1 CRY2 IDH3B IMP3 LRR1 MUTYH SERP1 SLC7A10 TNFRSF4 TNFSF9 TRAF1 TRAF2 TRAF3
Entrez ID		56301	3604
HPRD ID		12137	03767
Ensembl ID		ENSG00000130876	ENSG00000049249
Uniprot IDs		K7EK24 Q9NS82	Q07011
PDB IDs		8QEY 8WNS 8WNT 8WNY	6A3V 6A3W 6BWV 6CPR 6CU0 6MGP 6MHR 6MI2 6Y8K 7D4B 7YXU 8GYE 8OZ3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Basolateral Plasma Membrane Apical Pole Of Neuron Isoleucine Transport L-histidine Transport Exogenous Protein Binding Methionine Transport L-leucine Transmembrane Transporter Activity L-leucine Import Across Plasma Membrane Phenylalanine Transport Amino Acid Transport Complex L-alanine Transmembrane Transport Aromatic Amino Acid Transmembrane Transporter Activity Valine Transport Tryptophan Transport L-alanine Import Across Plasma Membrane Tyrosine Transport Positive Regulation Of Tooth Mineralization L-alanine Transmembrane Transporter Activity Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation L-alanine Transport Amelogenesis L-leucine Transport Proline Transport Organic Anion Transport ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Aromatic Amino Acid Transport Branched-chain Amino Acid Transport Thyroid Hormone Transport Apical Plasma Membrane Lysosomal Membrane Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Alanine Transport Sulfur Amino Acid Transport Cellular Response To Forskolin Response To Forskolin	Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Binding Signaling Adaptor Activity CD40 Receptor Complex Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Photoreactive Repair Adenine/guanine Mispair Binding TORC2 Complex Disassembly Positive Regulation Of Synaptic Transmission, Glycinergic D-serine Transmembrane Transport D-alanine Transmembrane Transport Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of NF-kappaB Transcription Factor Activity TRAF2-GSTP1 Complex TORC1 Complex Assembly Regulation Of Immunoglobulin Production CD40 Receptor Binding Positive Regulation Of Cytotoxic T Cell Differentiation Regulation Of Synaptic Transmission, Glycinergic Cry-Per Complex Isocitrate Dehydrogenase (NAD+) Activity Isocitrate Dehydrogenase Complex (NAD+) MutLbeta Complex Binding MutSbeta Complex Binding Protein Phosphatase Binding Mpp10 Complex Protein Secretion Protein Localization To Extracellular Region Basolateral Protein Secretion Establishment Of Protein Localization To Extracellular Region Negative Regulation Of Glucocorticoid Secretion Regulation Of Sodium-dependent Phosphate Transport Isocitrate Metabolic Process Depurination Regulation Of Programmed Cell Death Positive Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Ligase Complex Sphingolipid Binding Cytoplasmic Side Of Plasma Membrane IRE1-TRAF2-ASK1 Complex
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