TNFRSF9 and IMP3

		TNFRSF9	IMP3
Description		TNF receptor superfamily member 9	IMP U3 small nucleolar ribonucleoprotein 3
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Nucleus Nucleoplasm Nucleolus Cytosol Preribosome Small-subunit Processome Mpp10 Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding Signaling Receptor Activity	RNA Binding Protein Binding RRNA Binding SnoRNA Binding
	Biological Process	Apoptotic Process Negative Regulation Of Cell Population Proliferation Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Cell Population Proliferation	RRNA Processing Maturation Of SSU-rRNA Ribosome Biogenesis Ribosomal Small Subunit Biogenesis
Pathways		TNFs bind their physiological receptors	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Urelumab
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Celiac disease ( 20190752) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Psoriasis ( 23143594 25903422) Rheumatoid arthritis ( 24390342 30423114) Ulcerative colitis ( 21297633 28067908) Waist-hip ratio ( 28552196)
Interacting Genes		13 interacting genes: AP1S1 CRY2 IDH3B IMP3 LRR1 MUTYH SERP1 SLC7A10 TNFRSF4 TNFSF9 TRAF1 TRAF2 TRAF3	15 interacting genes: CCNDBP1 EFHC1 EVI5 KLC3 LPXN MPHOSPH10 NANOS3 PPP1R12C SERTAD3 SORBS3 TFIP11 TNFRSF9 USHBP1 ZNF655 ZYX
Entrez ID		3604	55272
HPRD ID		03767	12664
Ensembl ID		ENSG00000049249	ENSG00000177971
Uniprot IDs		Q07011	Q9NV31
PDB IDs		6A3V 6A3W 6BWV 6CPR 6CU0 6MGP 6MHR 6MI2 6Y8K 7D4B 7YXU 8GYE 8OZ3	2CQJ 7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Binding Signaling Adaptor Activity CD40 Receptor Complex Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Photoreactive Repair Adenine/guanine Mispair Binding TORC2 Complex Disassembly Positive Regulation Of Synaptic Transmission, Glycinergic D-serine Transmembrane Transport D-alanine Transmembrane Transport Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of NF-kappaB Transcription Factor Activity TRAF2-GSTP1 Complex TORC1 Complex Assembly Regulation Of Immunoglobulin Production CD40 Receptor Binding Positive Regulation Of Cytotoxic T Cell Differentiation Regulation Of Synaptic Transmission, Glycinergic Cry-Per Complex Isocitrate Dehydrogenase (NAD+) Activity Isocitrate Dehydrogenase Complex (NAD+) MutLbeta Complex Binding MutSbeta Complex Binding Protein Phosphatase Binding Mpp10 Complex Protein Secretion Protein Localization To Extracellular Region Basolateral Protein Secretion Establishment Of Protein Localization To Extracellular Region Negative Regulation Of Glucocorticoid Secretion Regulation Of Sodium-dependent Phosphate Transport Isocitrate Metabolic Process Depurination Regulation Of Programmed Cell Death Positive Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Ligase Complex Sphingolipid Binding Cytoplasmic Side Of Plasma Membrane IRE1-TRAF2-ASK1 Complex
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