PROX1 and LBH

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PROX1	LBH
Description		prospero homeobox 1	LBH regulator of Wnt signaling pathway
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Protein-containing Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Nuclear Receptor Binding Sequence-specific DNA Binding DNA Binding Domain Binding LBD Domain Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Liver Development Positive Regulation Of Endothelial Cell Proliferation Lymph Vessel Development Lymphangiogenesis Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Hepatocyte Cell Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Central Nervous System Development Brain Development Circadian Rhythm Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Epithelial Cell Migration Dorsal Spinal Cord Development Dentate Gyrus Development Cerebellar Granule Cell Differentiation Neural Tube Development Skeletal Muscle Thin Filament Assembly Lung Development Olfactory Placode Formation Pancreas Development Response To Nutrient Levels Tube Development Regulation Of Circadian Rhythm Otic Placode Formation Negative Regulation Of Viral Genome Replication Cell Fate Commitment Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Lens Placode Formation Involved In Camera-type Eye Formation Rhythmic Process Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Determination Inner Ear Development Venous Blood Vessel Morphogenesis Ventricular Cardiac Myofibril Assembly Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Retina Morphogenesis In Camera-type Eye Embryonic Retina Morphogenesis In Camera-type Eye Endocardium Formation Positive Regulation Of Sarcomere Organization Ventricular Septum Morphogenesis Aorta Smooth Muscle Tissue Morphogenesis Positive Regulation Of Heart Growth Lymphatic Endothelial Cell Differentiation Blood Vessel Endothelial Cell Differentiation Lymphatic Endothelial Cell Fate Commitment Branching Involved In Pancreas Morphogenesis Lens Fiber Cell Morphogenesis Hepatocyte Differentiation Negative Regulation Of Bile Acid Biosynthetic Process Hepatocyte Proliferation Acinar Cell Differentiation Neuronal Stem Cell Population Maintenance Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Cell Cycle Checkpoint Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Forebrain Neuron Differentiation	Regulation Of DNA-templated Transcription Regulation Of Gene Expression Mammary Gland Development Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Somatic Stem Cell Population Maintenance Positive Regulation Of Somatic Stem Cell Division Positive Regulation Of Mammary Stem Cell Proliferation Negative Regulation Of Stem Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Birth weight ( 31043758) Blood glucose levels ( 31928498) Breast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy ( 29059430) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Glycemic traits (pleiotropy) ( 31021400) Hematocrit ( 29403010 32888494 27863252) Hemoglobin ( 32888494 29403010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) HIV-1 progression ( 20064070) Homeostasis model assessment of beta-cell function ( 20081858) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monoclonal gammopathy of undetermined significance ( 30737484) Obesity ( 23818313) Pancreas volume ( 34128465) Red blood cell count ( 29403010 32888494 27863252) Refractive error ( 32231278) Rheumatic heart disease ( 34106200) Serum alkaline phosphatase levels ( 33547301) Triglycerides ( 25961943) Type 2 diabetes ( 30297969 32499647 29358691 28566273 24509480 22885922) Type 2 diabetes (age of onset) ( 28060188)	Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) HDL cholesterol levels ( 32203549) Height ( 18391951) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Primary biliary cholangitis ( 26394269) Refractive error ( 32231278) Reticulocyte count ( 32888494) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 28714469 27399966 33272962) vWF and FVIII levels ( 21810271) White blood cell count ( 32888494)
Interacting Genes		18 interacting genes: CREBBP CTBP2 EP300 ESRRA ESRRG GIT2 HNF4A IRF4 LBH NEK2 NR3C2 NR5A1 NR5A2 PAX6 PPARD RORA SMAD3 ZBTB3	2 interacting genes: CRYAB PROX1
Entrez ID		5629	81606
HPRD ID		03330	13965
Ensembl ID		ENSG00000117707	ENSG00000213626
Uniprot IDs		Q92786	Q53QV2
PDB IDs		2LMD
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Sequence-specific DNA Binding Chromatin Transcription Coregulator Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription Coactivator Binding Sequence-specific Double-stranded DNA Binding Zinc Ion Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Nuclear Steroid Receptor Activity Hormone-mediated Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Estrogen Response Element Binding Rhythmic Process Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intracellular Signal Transduction Chromatin Binding Metal Ion Binding Nucleus Histone H3K27 Acetyltransferase Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Chromatin DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity	Lens Development In Camera-type Eye Otic Placode Formation Hepatocyte Cell Migration Positive Regulation Of Forebrain Neuron Differentiation Branching Involved In Pancreas Morphogenesis Regulation Of Supramolecular Fiber Organization Cardiac Myofibril Cerebellar Granule Cell Differentiation Positive Regulation Of Sarcomere Organization Negative Regulation Of Bile Acid Biosynthetic Process Blood Vessel Endothelial Cell Differentiation Endocardium Formation Olfactory Placode Formation Lymphatic Endothelial Cell Fate Commitment Atrial Cardiac Muscle Tissue Morphogenesis Embryonic Retina Morphogenesis In Camera-type Eye Regulation Of Forebrain Neuron Differentiation Lens Placode Formation Involved In Camera-type Eye Formation Aorta Smooth Muscle Tissue Morphogenesis Hepatocyte Proliferation Lens Fiber Cell Morphogenesis Lymphatic Endothelial Cell Differentiation DNA Binding Domain Binding LBD Domain Binding Acinar Cell Differentiation Dorsal Spinal Cord Development Ventricular Cardiac Myofibril Assembly Skeletal Muscle Thin Filament Assembly Regulation Of Sarcomere Organization Actin Filament Bundle Venous Blood Vessel Morphogenesis Regulation Of Bile Acid Biosynthetic Process Tubulin Complex Assembly Neuron Fate Determination Regulation Of Growth Regulation Of Bile Acid Metabolic Process Negative Regulation Of Amyloid Fibril Formation Contractile Muscle Fiber Lymph Vessel Development Lymphangiogenesis Hepatocyte Differentiation Retina Morphogenesis In Camera-type Eye Negative Regulation Of Neuroblast Proliferation Lens Morphogenesis In Camera-type Eye Epithelial Cell Fate Commitment Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Cardiac Myofibril Assembly Glutamatergic Neuron Differentiation Regulation Of Amyloid Fibril Formation Positive Regulation Of Cell Cycle Checkpoint
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