PRKG2 and MYLK

Number of citations of the paper that reports this interaction (PubMedID 6547441)
0

Data Source:
HPRD (in vitro)

		PRKG2	MYLK
Description		protein kinase cGMP-dependent 2	myosin light chain kinase
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Apical Plasma Membrane Nuclear Membrane	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Lamellipodium Cleavage Furrow Cell Projection Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding Kinase Activity Transferase Activity CGMP Binding Identical Protein Binding Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	Nucleotide Binding Actin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Myosin Light Chain Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Scaffold Protein Binding
	Biological Process	Protein Phosphorylation Signal Transduction Positive Regulation Of Chondrocyte Differentiation Tetrahydrobiopterin Metabolic Process Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization Negative Regulation Of Chloride Transport	Protein Phosphorylation Smooth Muscle Contraction Muscle Organ Development Tonic Smooth Muscle Contraction Positive Regulation Of Cell Migration Bleb Assembly Positive Regulation Of Calcium Ion Transport Aorta Smooth Muscle Tissue Morphogenesis Cellular Hypotonic Response Positive Regulation Of Wound Healing Regulation Of Synaptic Vesicle Endocytosis
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Ca2+ pathway cGMP effects cGMP effects RAS processing	Smooth Muscle Contraction RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs		Fostamatinib	Ritodrine Fostamatinib
Diseases			Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Blood pressure (smoking interaction) ( 25189868) Body size at age 10 ( 32376654) Height ( 19343178 31562340 28552196 18391951 33713608 25282103 23563607) Hip circumference adjusted for BMI ( 25673412 34021172) HIV-1 susceptibility ( 22174851) Pubertal anthropometrics ( 23449627) Refractive error ( 32231278) Schizophrenia ( 33169155) Sleep duration (short sleep) ( 30846698) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172)	General cognitive ability ( 29844566)
Interacting Genes		8 interacting genes: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS RAB11B WDR77	15 interacting genes: ACTA1 ACTC1 APPBP2 CALM1 CAMK2G CTTN GOPC HSPB1 MAPK3 MLC1 PAK1 PAK2 PRKCA PRKG2 SRC
Entrez ID		5593	4638
HPRD ID		09034	02952
Ensembl ID		ENSG00000138669	ENSG00000065534
Uniprot IDs		A0A140VJM3 B4DLF9 B7ZA25 Q13237	A0A8I5KTQ1 A0A8I5KU53 Q05B97 Q05B98 Q15746
PDB IDs		5BV6 5C6C 5C8W 5JIX 5JIZ 6BQ8	2CQV 2K0F 2YR3 5JQA 5JTH 6C6M
Enriched GO Terms of Interacting Partners?		Cadherin Binding Monoatomic Ion Transport Postsynaptic Cytosol Receptor Metabolic Process Formation Of Structure Involved In A Symbiotic Process 6-pyruvoyltetrahydropterin Synthase Activity Oocyte Axis Specification Actin Binding Cytoplasm Regulation Of Monoatomic Ion Transport Myosin Light Chain Kinase Activity Channel Inhibitor Activity Ubiquitin Ligase Complex Phosphothreonine Residue Binding Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Cell Cortex Aorta Smooth Muscle Tissue Morphogenesis Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Metal Ion Transport Beta-2 Adrenergic Receptor Binding Protein Modification By Small Protein Conjugation Protein Ubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane Phosphatidylinositol Phospholipase C Activity Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Tetrahydrobiopterin Biosynthetic Process Constitutive Secretory Pathway Amyloid-beta Clearance By Transcytosis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cul4B-RING E3 Ubiquitin Ligase Complex Monoatomic Ion Transmembrane Transporter Activity Protein Modification Process Tonic Smooth Muscle Contraction Hypotonic Response Cellular Hypotonic Response Calmodulin Binding Bleb Assembly Sodium Channel Inhibitor Activity Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Regulation Of Potassium Ion Export Across Plasma Membrane Monoatomic Cation Transport Progesterone Receptor Signaling Pathway Endocardial Cushion Development Potassium Channel Inhibitor Activity Ubiquitin-protein Transferase Activity Phospholipase C Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway	Actin Filament Focal Adhesion Protein Kinase Activity ATP Binding Cytoskeleton Protein Serine Kinase Activity Kinase Activity Protein Serine/threonine Kinase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Muscle System Process Nucleotide Binding Intracellular Protein Localization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of System Process Mesenchyme Migration Positive Regulation Of Locomotion Caveolin-mediated Endocytosis Protein Phosphorylation Skeletal Muscle Thin Filament Assembly Sarcomere Cytosol Phosphorylation Lamellipodium Regulation Of Transport Cell-cell Junction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Caveola Cytoplasm Identical Protein Binding Negative Regulation Of Apoptotic Process Regulation Of Monoatomic Anion Transport Regulation Of Cellular Localization Cellular Response To Nutrient Levels Negative Regulation Of Programmed Cell Death Cell Junction Assembly Regulation Of Protein Localization Positive Regulation Of Cell Migration Protein Tyrosine Kinase Activator Activity Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Cell Motility Regulation Of Early Endosome To Late Endosome Transport Response To Growth Factor Protein Autophosphorylation Enzyme-linked Receptor Protein Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Locomotion Regulation Of MAPK Cascade ERBB2 Signaling Pathway
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