PRKG2 and LASP1

Number of citations of the paper that reports this interaction (PubMedID 12571245)
0

Data Source:
HPRD (in vitro, in vivo)

		PRKG2	LASP1
Description		protein kinase cGMP-dependent 2	LIM and SH3 protein 1
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Apical Plasma Membrane Nuclear Membrane	Cytoplasm Cytoskeleton Focal Adhesion Cell Cortex Cortical Actin Cytoskeleton Postsynapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding Kinase Activity Transferase Activity CGMP Binding Identical Protein Binding Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	Actin Binding Protein Binding Monoatomic Ion Transmembrane Transporter Activity Cadherin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Protein Phosphorylation Signal Transduction Positive Regulation Of Chondrocyte Differentiation Tetrahydrobiopterin Metabolic Process Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization Negative Regulation Of Chloride Transport	Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Ca2+ pathway cGMP effects cGMP effects RAS processing
Drugs		Fostamatinib
Diseases
GWAS		Blood pressure (smoking interaction) ( 25189868) Body size at age 10 ( 32376654) Height ( 19343178 31562340 28552196 18391951 33713608 25282103 23563607) Hip circumference adjusted for BMI ( 25673412 34021172) HIV-1 susceptibility ( 22174851) Pubertal anthropometrics ( 23449627) Refractive error ( 32231278) Schizophrenia ( 33169155) Sleep duration (short sleep) ( 30846698) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)
Interacting Genes		8 interacting genes: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS RAB11B WDR77	122 interacting genes: ACD ACTA1 ACTB ACTC1 ACTMAP ANKS1A ARHGEF15 ARHGEF16 ARID5A ATXN1 BAG4 BAHD1 BHLHE40 C14orf119 CAMK2A CATSPER1 CDK7 CEBPA CERCAM CHERP COPS5 CRK CRYBA1 CRYBA2 CSTF2T CTNNA3 CYSRT1 DAZAP2 DMRT3 DNMT1 DOK6 DRC4 DTX2 EHMT2 EVX2 FAM168A FAM168B FBXO17 FHL3 FOXH1 FXR2 GCM2 GOLGA2 GUCD1 HGS HNRNPF HOXA1 INTS11 KRTAP10-8 KRTAP12-4 KRTAP19-3 KRTAP19-4 KRTAP19-6 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP6-2 LENG8 LMO4 LZTS2 MDFI MED25 MGAT5B MKRN3 NOXA1 NUTF2 OTX1 OXER1 PITX1 PLSCR1 POLD1 POT1 POU1F1 PRKAR2B PRKG1 PRKG2 PRR20A PRR20B PRR20C PRR20D PRR20E PRR35 PSMA3 QRICH1 RBFOX1 RBPMS RBPMS2 REL RHOXF2 RNF38 SAXO4 SEPTIN3 SPAG8 SPRY2 ST3GAL3 STAT3 TCF4 TEKT3 TEKT4 TEKT5 TERF1 TFG THAP1 TINF2 TLX3 TNS2 TRIM27 TRIP13 UFSP1 UHRF1 VAC14 VEZF1 VGLL3 VPS37C WWOX YES1 YTHDF1 ZBTB9 ZC2HC1A ZC3H10 ZYX
Entrez ID		5593	3927
HPRD ID		09034	04229
Ensembl ID		ENSG00000138669	ENSG00000002834
Uniprot IDs		A0A140VJM3 B4DLF9 B7ZA25 Q13237	B4DIC4 Q14847
PDB IDs		5BV6 5C6C 5C8W 5JIX 5JIZ 6BQ8	3I35
Enriched GO Terms of Interacting Partners?		Cadherin Binding Monoatomic Ion Transport Postsynaptic Cytosol Receptor Metabolic Process Formation Of Structure Involved In A Symbiotic Process 6-pyruvoyltetrahydropterin Synthase Activity Oocyte Axis Specification Actin Binding Cytoplasm Regulation Of Monoatomic Ion Transport Myosin Light Chain Kinase Activity Channel Inhibitor Activity Ubiquitin Ligase Complex Phosphothreonine Residue Binding Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Cell Cortex Aorta Smooth Muscle Tissue Morphogenesis Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Metal Ion Transport Beta-2 Adrenergic Receptor Binding Protein Modification By Small Protein Conjugation Protein Ubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane Phosphatidylinositol Phospholipase C Activity Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Tetrahydrobiopterin Biosynthetic Process Constitutive Secretory Pathway Amyloid-beta Clearance By Transcytosis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cul4B-RING E3 Ubiquitin Ligase Complex Monoatomic Ion Transmembrane Transporter Activity Protein Modification Process Tonic Smooth Muscle Contraction Hypotonic Response Cellular Hypotonic Response Calmodulin Binding Bleb Assembly Sodium Channel Inhibitor Activity Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Regulation Of Potassium Ion Export Across Plasma Membrane Monoatomic Cation Transport Progesterone Receptor Signaling Pathway Endocardial Cushion Development Potassium Channel Inhibitor Activity Ubiquitin-protein Transferase Activity Phospholipase C Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway	Identical Protein Binding Protein Binding Shelterin Complex Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Nuclear Telomere Cap Complex Axonemal A Tubule Inner Sheath Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Capping Telomere Assembly Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Sperm Flagellum Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Flagellated Sperm Motility Sperm Motility Cilium-dependent Cell Motility Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cilium Movement Involved In Cell Motility Telomeric DNA Binding Neuron Fate Specification Regulation Of Macromolecule Metabolic Process CGMP-dependent Protein Kinase Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cytoplasmic Stress Granule DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of DNA Biosynthetic Process Chromatin Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Nucleus DNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Telomere Maintenance Regulation Of Metabolic Process Cilium Movement Negative Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Transcription Regulator Complex Mesenchyme Migration
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