LANCL2 and HLCS

		LANCL2	HLCS
Description		LanC like glutathione S-transferase 2	holocarboxylase synthetase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Cortical Actin Cytoskeleton	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	Protein Binding ATP Binding GTP Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding	Nucleotide Binding Catalytic Activity Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Enzyme Binding Identical Protein Binding
	Biological Process	Carbohydrate Metabolic Process Positive Regulation Of Abscisic Acid-activated Signaling Pathway Peptide Modification Negative Regulation Of DNA-templated Transcription	Biotin Metabolic Process Post-translational Protein Modification Response To Biotin
Pathways			Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs			Biotin
Diseases			Holocarboxylase synthetase deficiency
GWAS		Impulsivity ( 30718321) Mercury levels ( 26025379) Metabolite levels ( 23823483) QRS interval (sulfonylurea treatment interaction) ( 27958378) Spatial processing ( 31596458)	Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)
Interacting Genes		10 interacting genes: AKT1 APP APPBP2 HLCS RHOU SIAH1 TDRKH TERF2 TERF2IP UBC	19 interacting genes: ACACB ANKRD29 BACH1 DDX52 IFNAR2 IFNGR2 IFT20 KRTAP5-9 LANCL2 MED19 NGB POT1 QKI SARS2 SNX27 SOD1 TGM3 TXNDC15 WIPF1
Entrez ID		55915	3141
HPRD ID		13956	08360
Ensembl ID		ENSG00000132434	ENSG00000159267
Uniprot IDs		B3KTN5 Q9NS86	A0A8C8QSB1 P50747
PDB IDs		6WQ1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Recombination At Telomere Shelterin Complex Protection From Non-homologous End Joining At Telomere Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Protein Localization To Chromosome, Telomeric Region Telomere Capping Telomere Maintenance In Response To DNA Damage Enzyme Binding Post-translational Protein Modification RNA-templated DNA Biosynthetic Process Amyloid Fibril Formation Telomeric DNA Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of Telomere Maintenance Positive Regulation Of Nitric Oxide Metabolic Process Protein Ubiquitination Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Regulation Of Nitric Oxide Biosynthetic Process Protein Modification By Small Protein Conjugation Positive Regulation Of DNA Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of TRNA Methylation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Negative Regulation Of DNA Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Male Germ Cell Nucleus Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Lymphocyte Migration Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Macromolecule Metabolic Process Negative Regulation Of Protein Localization To Lysosome Acetylcholine Receptor Activator Activity Axo-dendritic Transport
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