CMAS and KCNJ6

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		CMAS	KCNJ6
Description		cytidine monophosphate N-acetylneuraminic acid synthetase	potassium inwardly rectifying channel subfamily J member 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane	Golgi Apparatus Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex
	Molecular Function	N-acylneuraminate Cytidylyltransferase Activity Transferase Activity Nucleotidyltransferase Activity	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity
	Biological Process	N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process Glycosylation	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Sialic acid metabolism	Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Cytidine-5'-Monophosphate-5-N-Acetylneuraminic Acid	Ethanol Halothane Ifenprodil Isavuconazole
Diseases
GWAS		Entorhinal cortical thickness ( 21116278)	Body size at age 10 ( 32376654) Clostridioides difficle infection ( 33841421) Electroencephalographic traits in alcoholism ( 22554406) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Rosacea symptom severity ( 29771307)
Interacting Genes		5 interacting genes: APP KCNJ6 PTEN RSPH1 SIGLEC12	71 interacting genes: ADRB2 AIG1 APOD BCL2L2 BET1 BIRC5 C14orf180 CMAS CMTM5 CNPY3 COL4A5 CXXC5 DLG1 DRD2 EDDM3B ERG28 FAM20B FIS1 FUNDC2 FXYD6 GABBR1 GIPC1 HMOX2 ICMT ITGAM KCNJ3 KCNJ9 LEPROTL1 LPAR3 LPCAT2 MAP1S MIP MYO15B NINJ2 ORMDL2 PEX11G PEX16 PICK1 PLLP PMP22 PNLIPRP1 PTPRD RPRM RPS6KA2 RTP2 SCAMP4 SCARF1 SCD SERTM1 STATH STRIT1 SYT3 THSD7B TM6SF2 TMEM107 TMEM120B TMEM203 TMEM208 TMEM218 TMPPE TNFRSF10C TSPO2 UBIAD1 UNC50 UPK1B VSTM1 XIAP YIPF1 YIPF6 ZBTB38 ZDHHC24
Entrez ID		55907	3763
HPRD ID		04501	02929
Ensembl ID		ENSG00000111726	ENSG00000157542
Uniprot IDs		Q8NFW8	P48051
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Excitatory Postsynaptic Potential Reproductive Behavior Neuron Projection Organization Modulation Of Excitatory Postsynaptic Potential Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Central Nervous System Development Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Adult Behavior Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Dendritic Spine Positive Regulation Of G Protein-coupled Receptor Internalization Axonogenesis Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Radial Spoke Head 1 Radial Spoke Head 3 Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Developmental Maturation Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Microtubule-based Process Main Axon Locomotory Behavior Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling G-protein Activated Inward Rectifier Potassium Channel Activity	Membrane Presynaptic Membrane Trans-synaptic Signaling Synaptic Signaling Endoplasmic Reticulum Membrane Protein Binding Endoplasmic Reticulum Chemical Synaptic Transmission Negative Regulation Of Dopamine Secretion G-protein Activated Inward Rectifier Potassium Channel Activity Compact Myelin Inward Rectifier Potassium Channel Complex Regulation Of Sodium Ion Transport Protein Targeting Regulation Of Presynaptic Membrane Potential Regulation Of Monoatomic Ion Transport Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Golgi Trans Cisterna Negative Regulation Of Synaptic Transmission
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