KIZ and OVOL2

		KIZ	OVOL2
Description		kizuna centrosomal protein	ovo like zinc finger 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Cell Projection	Nucleus
	Molecular Function	Protein Binding Protein Kinase Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Spindle Organization	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Neural Crest Cell Migration Neural Fold Formation Heart Looping Regulation Of Transcription By RNA Polymerase II Heart Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epidermis Development Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Keratinocyte Proliferation Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Differentiation Regulation Of Keratinocyte Differentiation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Digestive Tract Morphogenesis Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Cycle Endocardium Formation Heart Trabecula Formation Negative Regulation Of SMAD Protein Signal Transduction Labyrinthine Layer Blood Vessel Development White Fat Cell Proliferation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Stem Cell Proliferation
Pathways
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Autism spectrum disorder ( 30804558) Height ( 31562340)	Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Nicotine dependence symptom count ( 25555482) Red blood cell count ( 32888494)
Interacting Genes		14 interacting genes: AAR2 ANKEF1 CDK5RAP1 CRYAA EIF2S2 MEOX2 NKX2-2 OVOL2 PRND RASSF2 SAMHD1 SPEF1 TACC3 TFIP11	6 interacting genes: KIZ MDM2 NCOR1 PARP1 RELA ZNF526
Entrez ID		55857	58495
HPRD ID		12760	15780
Ensembl ID		ENSG00000088970	ENSG00000125850
Uniprot IDs		A0A087X251 Q2M2Z5	Q9BRP0
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Organization Ventral Spinal Cord Interneuron Fate Determination Type B Pancreatic Cell Fate Commitment DGTPase Activity DGTP Binding Triphosphoric Monoester Hydrolase Activity Deoxynucleoside Triphosphate Hydrolase Activity Positive Regulation Of Translational Fidelity TRNA-2-methylthio-N(6)-dimethylallyladenosine(37) Synthase Activity	Response To UV Cellular Response To Oxidative Stress Negative Regulation Of ATP Metabolic Process Histone Deacetylase Binding Response To Steroid Hormone Cellular Response To Peptide Hormone Stimulus Negative Regulation Of MiRNA Transcription Negative Regulation Of Intracellular Signal Transduction Signal Transduction Involved In Regulation Of Gene Expression Cellular Response To Chemical Stress Response To Alcohol Cellular Response To Growth Factor Stimulus Ubiquitin Protein Ligase Binding Response To Peptide Hormone Response To Light Stimulus Response To Growth Factor Negative Regulation Of Transcription By RNA Polymerase II Response To Gamma Radiation Cellular Response To Hormone Stimulus Response To Oxidative Stress Regulation Of ATP Metabolic Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity Enzyme Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Regulation Of Purine Nucleotide Metabolic Process Protein Kinase Binding NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Regulation Of Apoptotic Signaling Pathway NAD+-protein-histidine ADP-ribosyltransferase Activity Response To Radiation NAD+-protein-tyrosine ADP-ribosyltransferase Activity Transcription Repressor Complex Response To Vitamin Response To Formaldehyde Cellular Response To Vitamin B1 Cellular Response To Hydrogen Peroxide Regulation Of MiRNA Transcription Cellular Response To UV Response To Alkaloid Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Hydrogen Peroxide Cellular Response To Light Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Cellular Response To Reactive Oxygen Species Positive Regulation Of Myofibroblast Differentiation NAD+-protein-serine ADP-ribosyltransferase Activity
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