KIZ and CDK5RAP1

		KIZ	CDK5RAP1
Description		kizuna centrosomal protein	CDK5RAP1 mitochondrial tRNA methylthiotransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Cell Projection	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Protein Binding Protein Kinase Binding	Catalytic Activity Transferase Activity Protein Kinase Binding Methylthiotransferase Activity TRNA-2-methylthio-N(6)-dimethylallyladenosine(37) Synthase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Spindle Organization	TRNA Modification Brain Development TRNA Processing RNA Modification TRNA Methylthiolation Regulation Of Neuron Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Translational Fidelity Regulation Of Protein Metabolic Process Positive Regulation Of Mitochondrial Translation Mitochondrial TRNA Modification
Pathways
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Autism spectrum disorder ( 30804558) Height ( 31562340)	Diastolic blood pressure ( 30224653) Hip circumference adjusted for BMI ( 25673412 34021172) Mean corpuscular volume ( 32888494)
Interacting Genes		14 interacting genes: AAR2 ANKEF1 CDK5RAP1 CRYAA EIF2S2 MEOX2 NKX2-2 OVOL2 PRND RASSF2 SAMHD1 SPEF1 TACC3 TFIP11	7 interacting genes: CDK5 CDK5R1 EXOSC3 EXOSC5 KIZ NKX2-2 PPP1R16B
Entrez ID		55857	51654
HPRD ID		12760	12189
Ensembl ID		ENSG00000088970	ENSG00000101391
Uniprot IDs		A0A087X251 Q2M2Z5	A0A0S2Z592 A0A0S2Z5J9 Q53H36 Q96SZ6
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Organization Ventral Spinal Cord Interneuron Fate Determination Type B Pancreatic Cell Fate Commitment DGTPase Activity DGTP Binding Triphosphoric Monoester Hydrolase Activity Deoxynucleoside Triphosphate Hydrolase Activity Positive Regulation Of Translational Fidelity TRNA-2-methylthio-N(6)-dimethylallyladenosine(37) Synthase Activity	Protein Kinase 5 Complex Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity DNA Deamination Nucleolar Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process Layer Formation In Cerebral Cortex SnRNA 3'-end Processing Positive Regulation Of Protein Targeting To Membrane DNA Modification Ionotropic Glutamate Receptor Binding 3'-5'-RNA Exonuclease Activity Regulation Of Protein Targeting To Membrane SnRNA Processing Nuclear RNA Surveillance RNA Surveillance Regulation Of Dendritic Spine Morphogenesis Oligodendrocyte Differentiation Cyclin-dependent Protein Kinase Holoenzyme Complex SnRNA Metabolic Process Cerebellum Development Euchromatin Glial Cell Development Neuron Differentiation Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Hippocampus Development Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Ventral Spinal Cord Interneuron Fate Determination Type B Pancreatic Cell Fate Commitment Neuromuscular Junction RNA 3'-end Processing Microtubule Cytoskeleton Organization Acetylcholine Receptor Activator Activity Glial Cell Differentiation Cell Projection Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Superior Olivary Nucleus Maturation Nuclear-transcribed MRNA Catabolic Process Regulation Of Developmental Process ErbB-2 Class Receptor Binding Negative Regulation Of Synaptic Plasticity Cerebellar Cortex Formation Epithelial Cell Development Spinal Cord Oligodendrocyte Cell Fate Specification
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