PRKCD and FSCN1

Number of citations of the paper that reports this interaction (PubMedID 8999969)
0

Data Source:
HPRD (in vitro)

		PRKCD	FSCN1
Description		protein kinase C delta	fascin actin-bundling protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Cell-cell Junction Endomembrane System Membrane Nuclear Matrix Azurophil Granule Lumen Endolysosome Perinuclear Region Of Cytoplasm Extracellular Exosome	Stress Fiber Ruffle Podosome Cytoplasm Cytosol Cytoskeleton Microvillus Cell-cell Junction Cell Cortex Actin Cytoskeleton Lamellipodium Filopodium Growth Cone Cell Leading Edge Cell Projection Membrane Cell Projection Microspike Extracellular Exosome Anchoring Junction
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Zinc Ion Binding Kinase Activity Transferase Activity Enzyme Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Insulin Receptor Substrate Binding Metal Ion Binding Protein Serine Kinase Activity	RNA Binding Actin Binding Protein Binding Protein-macromolecule Adaptor Activity Cadherin Binding Actin Filament Binding
	Biological Process	Protein Phosphorylation Apoptotic Process DNA Damage Response Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Immunoglobulin Mediated Immune Response Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Termination Of Signal Transduction Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Superoxide Anion Generation Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Glial Cell Apoptotic Process Cellular Response To UV Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis B Cell Proliferation Neutrophil Activation Positive Regulation Of Protein Import Into Nucleus Defense Response To Bacterium Negative Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Regulation Of MRNA Stability Post-translational Protein Modification Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Protein Stabilization Positive Regulation Of DNA Metabolic Process Negative Regulation Of Filopodium Assembly Cell Chemotaxis Cellular Response To Hydrogen Peroxide Protein Kinase C Signaling Cellular Response To Fatty Acid Cellular Response To Hydroperoxide Negative Regulation Of Platelet Aggregation Cellular Senescence Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Phospholipid Scramblase Activity Cellular Response To Angiotensin Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Actin Filament Organization Cell-cell Junction Assembly Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Lamellipodium Assembly Cell Migration Microspike Assembly Actin Cytoskeleton Organization Parallel Actin Filament Bundle Assembly Regulation Of Microvillus Assembly Regulation Of Actin Cytoskeleton Organization Establishment Of Apical/basal Cell Polarity Cell Motility Actin Filament Bundle Assembly Positive Regulation Of Filopodium Assembly Positive Regulation Of Podosome Assembly Positive Regulation Of Extracellular Matrix Disassembly
Pathways		Apoptotic cleavage of cellular proteins Calmodulin induced events Effects of PIP2 hydrolysis SHC1 events in ERBB2 signaling DAG and IP3 signaling Role of phospholipids in phagocytosis G alpha (z) signalling events HuR (ELAVL1) binds and stabilizes mRNA VEGFR2 mediated cell proliferation CLEC7A (Dectin-1) signaling RHO GTPases Activate NADPH Oxidases Neutrophil degranulation Interferon gamma signaling KEAP1-NFE2L2 pathway	Interleukin-4 and Interleukin-13 signaling
Drugs		Tamoxifen Staurosporine Dequalinium 13-Acetylphorbol Ingenol mebutate Benzoyl peroxide Fostamatinib
Diseases
GWAS		A body shape index ( 34021172) Bipolar disorder ( 21926972) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Ulcerative colitis ( 23128233) Waist circumference adjusted for body mass index ( 28552196 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		122 interacting genes: ACTA1 ACTA2 ACTB ADAM9 ADCY7 ADD1 ADD2 ADRA2A ADRB2 AFAP1 AKT3 APP ART3 BDKRB2 C1QBP CD34 CDCP1 CHAT CNP CREBBP CYTH1 DAB2 DYNC1H1 EEF1A1 EGFR EIF2S1 ELAVL1 EP300 ESRRA FLI1 FSCN1 FYN GABRA1 GAP43 GNA12 GNA13 GNAZ GRK2 GRM5 GSK3A H1-1 H1-5 HABP4 HDAC5 HNRNPK HSP90AA1 HSPA4 IGF1R IKBKB IL6ST INSR IRS1 ITGA6 ITGB2 ITGB4 ITGB7 ITPR1 KCNJ1 KCNJ4 KLF5 LCK LMNB1 LMNB2 LYN MACF1 MAPK1 MAPK3 MAPT MBP MEP1B MS4A2 MUC1 NCF1 NCF4 NFE2L2 NOTCH1 NSD1 NUMB OPRD1 PAK1 PDP1 PDP2 PDPK1 PEBP1 PIK3CA PIK3CB PLCB1 PLD2 PLSCR1 PLSCR3 PPARA PPM1A PPP1CA PPP2CA PPP2R5C PRKCZ PRKDC PTK2B PTOV1 PTPN22 PTPN6 PTPRA RAC1 RACK1 RAF1 RASGRP3 RIPK4 RUNX2 SDC4 SHC1 SPRY2 SQSTM1 SRC STAT1 STAT3 TAGLN TIAM1 TNFRSF1A VCP YWHAB YWHAG YWHAZ	15 interacting genes: ACTA1 ACTC1 CTNNB1 DNAJB9 MAD1L1 MAPK8IP2 MYCBP2 NGFR OXTR PRKCA PRKCD RAB1A SMURF1 USP10 YWHAQ
Entrez ID		5580	6624
HPRD ID		01501	04068
Ensembl ID		ENSG00000163932	ENSG00000075618
Uniprot IDs		B4DFV1 Q05655	A0A384MEG1 B3KTA3 Q16658
PDB IDs		1YRK 2YUU	1DFC 3LLP 3P53 4GOV 4GOY 4GP0 4GP3 6B0T 6I0Z 6I10 6I11 6I12 6I13 6I14 6I15 6I16 6I17 6I18 7ZAU 8VO5 8VO6 8VO7 8VO8 8VO9 8VOA
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Focal Adhesion Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Macromolecule Metabolic Process Intracellular Signaling Cassette Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MAPK Cascade Positive Regulation Of Cell Migration Regulation Of Apoptotic Process Regulation Of Transport Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Programmed Cell Death Positive Regulation Of Locomotion Regulation Of Metabolic Process Regulation Of Cell Motility Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cellular Component Organization Regulation Of Locomotion Regulation Of Macromolecule Metabolic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Cellular Response To Peptide Hormone Stimulus Regulation Of Protein Localization Positive Regulation Of Developmental Process Regulation Of Biological Quality Regulation Of Cell Adhesion Response To Peptide Hormone Regulation Of Macromolecule Biosynthetic Process	Extracellular Exosome Positive Regulation Of Metabolic Process Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Protein Kinase C Signaling Cytoplasm Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Intracellular Signaling Cassette Proteasomal Protein Catabolic Process Negative Regulation Of Glial Cell Apoptotic Process Ectoderm Development Developmental Process I-SMAD Binding Diacylglycerol-dependent Serine/threonine Kinase Activity Cytosol Positive Regulation Of Glycoprotein Metabolic Process Protein Catabolic Process Apoptotic Signaling Pathway Myosin Binding Transmembrane Transporter Binding Proteolysis Involved In Protein Catabolic Process Regulation Of Multicellular Organismal Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Regulation Of Platelet Aggregation Positive Regulation Of Gene Expression Regulation Of Synapse Assembly Negative Regulation Of Intracellular Signal Transduction Hair Follicle Morphogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Protein-containing Complex Central Nervous System Neuron Axonogenesis Lamellipodium Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Muscle Contraction Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Thymus Development Glial Cell Fate Determination SMAD Binding Cell-cell Junction Regulation Of Protein Localization
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