FSCN1 and DNAJB9

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FSCN1	DNAJB9
Description		fascin actin-bundling protein 1	DnaJ heat shock protein family (Hsp40) member B9
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GO Annotations	Cellular Component	Stress Fiber Ruffle Podosome Cytoplasm Cytosol Cytoskeleton Microvillus Cell-cell Junction Cell Cortex Actin Cytoskeleton Lamellipodium Filopodium Growth Cone Cell Leading Edge Cell Projection Membrane Cell Projection Microspike Extracellular Exosome Anchoring Junction	Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Extracellular Exosome
	Molecular Function	RNA Binding Actin Binding Protein Binding Protein-macromolecule Adaptor Activity Cadherin Binding Actin Filament Binding	Protein Binding Hsp70 Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding
	Biological Process	Actin Filament Organization Cell-cell Junction Assembly Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Lamellipodium Assembly Cell Migration Microspike Assembly Actin Cytoskeleton Organization Parallel Actin Filament Bundle Assembly Regulation Of Microvillus Assembly Regulation Of Actin Cytoskeleton Organization Establishment Of Apical/basal Cell Polarity Cell Motility Actin Filament Bundle Assembly Positive Regulation Of Filopodium Assembly Positive Regulation Of Podosome Assembly Positive Regulation Of Extracellular Matrix Disassembly	Positive Regulation Of Immunoglobulin Production Response To Unfolded Protein B Cell Differentiation Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response
Pathways		Interleukin-4 and Interleukin-13 signaling	XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS			Body size at age 10 ( 32376654) Metabolite levels ( 23823483) Smoking behavior ( 22006218)
Interacting Genes		15 interacting genes: ACTA1 ACTC1 CTNNB1 DNAJB9 MAD1L1 MAPK8IP2 MYCBP2 NGFR OXTR PRKCA PRKCD RAB1A SMURF1 USP10 YWHAQ	11 interacting genes: DYNLL1 ECPAS FSCN1 GARIN6 GRIK1 MYL6 PLK1 RFK SLC16A8 TCEA2 TCERG1
Entrez ID		6624	4189
HPRD ID		04068	07047
Ensembl ID		ENSG00000075618	ENSG00000128590
Uniprot IDs		A0A384MEG1 B3KTA3 Q16658	Q6FIF1 Q9UBS3
PDB IDs		1DFC 3LLP 3P53 4GOV 4GOY 4GP0 4GP3 6B0T 6I0Z 6I10 6I11 6I12 6I13 6I14 6I15 6I16 6I17 6I18 7ZAU 8VO5 8VO6 8VO7 8VO8 8VO9 8VOA	2CTR
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Positive Regulation Of Metabolic Process Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Protein Kinase C Signaling Cytoplasm Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Intracellular Signaling Cassette Proteasomal Protein Catabolic Process Negative Regulation Of Glial Cell Apoptotic Process Ectoderm Development Developmental Process I-SMAD Binding Diacylglycerol-dependent Serine/threonine Kinase Activity Cytosol Positive Regulation Of Glycoprotein Metabolic Process Protein Catabolic Process Apoptotic Signaling Pathway Myosin Binding Transmembrane Transporter Binding Proteolysis Involved In Protein Catabolic Process Regulation Of Multicellular Organismal Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Regulation Of Platelet Aggregation Positive Regulation Of Gene Expression Regulation Of Synapse Assembly Negative Regulation Of Intracellular Signal Transduction Hair Follicle Morphogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Protein-containing Complex Central Nervous System Neuron Axonogenesis Lamellipodium Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Muscle Contraction Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Thymus Development Glial Cell Fate Determination SMAD Binding Cell-cell Junction Regulation Of Protein Localization
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