SCYL2 and ZFYVE9

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		SCYL2	ZFYVE9
Description		SCY1 like pseudokinase 2	zinc finger FYVE-type containing 9
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Golgi Apparatus Endosome Membrane Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle	Cytoplasm Endosome Early Endosome Cytosol Membrane Early Endosome Membrane Protein-containing Complex
	Molecular Function	Protein Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding	Protein Binding 1-phosphatidylinositol Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Brain Development Endosome To Lysosome Transport Pyramidal Neuron Development Receptor Internalization Clathrin-dependent Endocytosis Negative Regulation Of Canonical Wnt Signaling Pathway	Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway Endosomal Transport
Pathways
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Squamous cell carcinoma ( 23341777)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: CLTC GTF3A RBM11 ZFYVE9	40 interacting genes: ANKLE2 ATP6V0B BAG6 BMP4 CHD6 CLTC CTNNB1 DAZAP2 EIF4G1 ERBIN ETS2 FHL2 JUP LRP12 NIT1 NRDC NUP155 PML PPP1CA PPP1CB PPP1CC PPP2R1A RBBP6 RHOT2 RNF11 RNPEP SCYL2 SMAD2 SMAD3 SPART ST7 SUMF2 SUPT5H SVEP1 TENT5A TGFBR1 TGFBR2 UBC UBXN11 ZMYND8
Entrez ID		55681	9372
HPRD ID		07642	04782
Ensembl ID		ENSG00000136021	ENSG00000157077
Uniprot IDs		A0A0U1RQQ9 Q6P3W7	O95405
PDB IDs			1DEV 1MK2 4BKW 5MJY
Enriched GO Terms of Interacting Partners?		Clathrin Coat Of Trans-Golgi Network Vesicle Vesicle Uncoating Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Hyaluronan Biosynthetic Process Clathrin Coat Clathrin Coat Of Coated Pit Endosomal Transport Clathrin Light Chain Binding Clathrin Coat Disassembly Amyloid-beta Clearance By Transcytosis Clathrin Complex Transferrin Transport RNA Binding 5S RRNA Binding 1-phosphatidylinositol Binding Transcytosis Endolysosome Membrane Endocytosis Ubiquitin-specific Protease Binding Mitotic Spindle Microtubule Clathrin Coat Assembly Clathrin-coated Endocytic Vesicle Low-density Lipoprotein Particle Receptor Binding Amyloid-beta Clearance Disordered Domain Specific Binding RRNA Transcription Poly(U) RNA Binding Nucleic Acid Binding Import Into Cell Negative Regulation Of Protein Localization To Plasma Membrane Clathrin-dependent Endocytosis Transcription By RNA Polymerase III Protein Depolymerization Ribosomal Large Subunit Biogenesis Regulation Of Mitotic Spindle Organization Iron Ion Transport Endosome Protein-containing Complex Single-stranded RNA Binding	Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Ubiquitin Protein Ligase Binding Embryonic Skeletal System Morphogenesis I-SMAD Binding SMAD Binding Lung Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Skeletal System Morphogenesis Entrainment Of Circadian Clock By Photoperiod Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction Trachea Formation Trophoblast Cell Migration PTW/PP1 Phosphatase Complex Embryonic Organ Morphogenesis Photoperiodism Entrainment Of Circadian Clock Activin Receptor Signaling Pathway Embryonic Foregut Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Cell Fate Commitment Tissue Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Tissue Development Gastrulation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Branching Involved In Lung Morphogenesis Tube Morphogenesis Positive Regulation Of Developmental Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription Elongation By RNA Polymerase II Mesenchyme Development Regulation Of Developmental Process Formation Of Primary Germ Layer Branching Morphogenesis Of An Epithelial Tube Osteoblast Differentiation Bronchus Development Animal Organ Formation Positive Regulation Of DNA-templated Transcription, Elongation Catenin-TCF7L2 Complex Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Regulation Of Translation In Response To Stress Circadian Regulation Of Gene Expression In Utero Embryonic Development Regulation Of SMAD Protein Signal Transduction Developmental Growth
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