ZFYVE9 and ANKLE2

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)

		ZFYVE9	ANKLE2
Description		zinc finger FYVE-type containing 9	ankyrin repeat and LEM domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Membrane Early Endosome Membrane Protein-containing Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding	Protein Kinase Inhibitor Activity Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase 2A Binding
	Biological Process	Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway Endosomal Transport	Mitotic Nuclear Membrane Reassembly Nervous System Development Central Nervous System Development Nuclear Membrane Reassembly Negative Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Cell Division
Pathways			Initiation of Nuclear Envelope (NE) Reformation RAC2 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Adult body size ( 32376654) Immune response to smallpox vaccine (IL-6) ( 22542470) Lymphocyte count ( 32888494) Refractive error ( 32231278)
Interacting Genes		40 interacting genes: ANKLE2 ATP6V0B BAG6 BMP4 CHD6 CLTC CTNNB1 DAZAP2 EIF4G1 ERBIN ETS2 FHL2 JUP LRP12 NIT1 NRDC NUP155 PML PPP1CA PPP1CB PPP1CC PPP2R1A RBBP6 RHOT2 RNF11 RNPEP SCYL2 SMAD2 SMAD3 SPART ST7 SUMF2 SUPT5H SVEP1 TENT5A TGFBR1 TGFBR2 UBC UBXN11 ZMYND8	3 interacting genes: MAPK13 ZFYVE9 ZNF512B
Entrez ID		9372	23141
HPRD ID		04782	19309
Ensembl ID		ENSG00000157077	ENSG00000176915
Uniprot IDs		O95405	Q86XL3
PDB IDs		1DEV 1MK2 4BKW 5MJY
Enriched GO Terms of Interacting Partners?		Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Ubiquitin Protein Ligase Binding Embryonic Skeletal System Morphogenesis I-SMAD Binding SMAD Binding Lung Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Skeletal System Morphogenesis Entrainment Of Circadian Clock By Photoperiod Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction Trachea Formation Trophoblast Cell Migration PTW/PP1 Phosphatase Complex Embryonic Organ Morphogenesis Photoperiodism Entrainment Of Circadian Clock Activin Receptor Signaling Pathway Embryonic Foregut Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Cell Fate Commitment Tissue Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Tissue Development Gastrulation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Branching Involved In Lung Morphogenesis Tube Morphogenesis Positive Regulation Of Developmental Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription Elongation By RNA Polymerase II Mesenchyme Development Regulation Of Developmental Process Formation Of Primary Germ Layer Branching Morphogenesis Of An Epithelial Tube Osteoblast Differentiation Bronchus Development Animal Organ Formation Positive Regulation Of DNA-templated Transcription, Elongation Catenin-TCF7L2 Complex Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Regulation Of Translation In Response To Stress Circadian Regulation Of Gene Expression In Utero Embryonic Development Regulation Of SMAD Protein Signal Transduction Developmental Growth	Response To Anisomycin Cellular Response To Anisomycin Response To Sodium Arsenite Cellular Response To Salt Cellular Response To Sorbitol Cellular Response To Sodium Arsenite Response To Sorbitol MAP Kinase Activity Cellular Response To Arsenic-containing Substance 1-phosphatidylinositol Binding Response To Salt Response To Arsenic-containing Substance Stress-activated Protein Kinase Signaling Cascade Stress-activated MAPK Cascade Negative Regulation Of MiRNA Transcription
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