BCAS4 and DPY30

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BCAS4	DPY30
Description		breast carcinoma amplified sequence 4	dpy-30 histone methyltransferase complex regulatory subunit
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm BLOC-1 Complex	Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex MLL1/2 Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process		Chromatin Organization Endosomal Transport Transcription Initiation-coupled Chromatin Remodeling
Pathways			PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome
Drugs
Diseases
GWAS		Basal cell carcinoma ( 31174203 33549134) Diffusing capacity of carbon monoxide ( 30694715) Keratinocyte cancer (MTAG) ( 31174203) Response to fenofibrate (total cholesterol levels) ( 27002377)	Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)
Interacting Genes		2 interacting genes: DPY30 ENKD1	33 interacting genes: AK8 AKAP14 ARFGEF1 ASH2L BCAS4 BEND3 CDK17 CFAP91 CHMP2B CREB3L3 DYDC1 DYDC2 FAM136A GPATCH2 GTF2I H3-4 ICA1L KMT2C MRFAP1 OTX1 PRPF3 PRRC2B PSMC3 PSMD14 PXN RSPH3 SETD1A TMCC2 TSPY10 TSPY2 TSPY3 UBC ZFYVE19
Entrez ID		55653	84661
HPRD ID		06314	17434
Ensembl ID		ENSG00000124243	ENSG00000162961
Uniprot IDs		A0A804CEY2 Q8TDM0	Q9C005
PDB IDs			3G36 4RIQ 4RT4 4RTA 6E2H 6PWV 7UD5
Enriched GO Terms of Interacting Partners?		Establishment Of Mitotic Spindle Localization Establishment Of Spindle Localization Establishment Of Spindle Orientation Alpha-tubulin Binding Non-motile Cilium Assembly Motile Cilium Assembly Establishment Of Mitotic Spindle Orientation 9+0 Non-motile Cilium Ciliary Base Cytoplasmic Microtubule Positive Regulation Of Gene Expression, Epigenetic Set1C/COMPASS Complex MLL1/2 Complex Histone Methyltransferase Complex MLL3/4 Complex MLL1 Complex Transcription Initiation-coupled Chromatin Remodeling Spindle Localization Establishment Of Localization In Cell	Set1C/COMPASS Complex Gonadal Mesoderm Development Histone Methyltransferase Complex Chromatin Remodeling Nucleosome Assembly Nucleosome Organization Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Chromatin Organization Mesoderm Development Mesenchyme Development MLL3/4 Complex Histone H3K4 Methyltransferase Activity Proteasome Accessory Complex Protein-DNA Complex Assembly Midbody Abscission Beta-catenin Binding Protein Kinase A Regulatory Subunit Binding Mitotic Cytokinetic Process 9+2 Motile Cilium Axoneme
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