LYAR and PRKRA

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		LYAR	PRKRA
Description		Ly1 antibody reactive	protein activator of interferon induced protein kinase EIF2AK2
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Nucleoplasm Nucleolus Cytoplasm Cell Projection	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane RISC Complex Perinuclear Region Of Cytoplasm RISC-loading Complex
	Molecular Function	DNA Binding RNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Activator Activity Enzyme Binding Protein Kinase Activator Activity SiRNA Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process RRNA Processing Innate Immune Response Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase I Erythrocyte Development Positive Regulation Of Phagocytosis	Immune Response Negative Regulation Of Cell Population Proliferation Response To Virus SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing Cellular Response To Oxidative Stress MiRNA Processing Outer Ear Morphogenesis Middle Ear Morphogenesis Ear Development Skeletal System Morphogenesis Protein Stabilization Regulation Of Regulatory NcRNA Processing RISC Complex Assembly Antiviral Innate Immune Response Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis PKR-mediated signaling
Drugs
Diseases			Primary torsion dystonia (PTD)
GWAS		Disease progression in age-related macular degeneration ( 29346644)	Inflammatory skin disease ( 25574825) Multiple sclerosis (OCB status) ( 23472185) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183)
Interacting Genes		16 interacting genes: ADSS1 BEND7 CD2 FGF18 GSK3B OGT PDE4B PHF20L1 PRKRA SDCBP2 SNRPA SREK1IP1 TERF1 TERF2 ZBTB16 ZHX1	35 interacting genes: ADARB1 AGO2 CAT CEBPZ CEP126 CLASP1 COPS6 DICER1 EHHADH EIF2AK2 FZD7 GDF9 H19 HEYL LNX1 LYAR NEIL3 NKRF PIAS2 PITPNM1 PLEKHA3 PNPT1 POLR2G RABEPK RB1 RBPMS SETDB1 SHC1 SNX5 TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZNF746
Entrez ID		55646	8575
HPRD ID		10064	04573
Ensembl ID		ENSG00000145220	ENSG00000180228
Uniprot IDs		Q9NX58	A0A7I2V2I8 A0A7I2V5H3 B4DJC7 O75569
PDB IDs		6ZMI 6ZMO 6ZVH	2DIX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Shelterin Complex Telomerase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly NSL Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Telomere Capping Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Protein Catabolic Process RNA-templated DNA Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Telomeric DNA Binding Protein Homodimerization Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Cartilage Development Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Telomere Maintenance Identical Protein Binding Nucleoplasm Regulation Of Proteasomal Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Macromolecule Metabolic Process Male Germ Cell Nucleus Regulation Of Chondrocyte Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of Metabolic Process Superior Temporal Gyrus Development	Double-stranded RNA Binding RISC-loading Complex SiRNA Processing RISC Complex Assembly SiRNA Binding Negative Regulation Of Macromolecule Metabolic Process Pre-miRNA Processing Positive Regulation Of RNA Metabolic Process Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Global Gene Silencing By MRNA Cleavage Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process RNA Binding Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Regulation Of Macromolecule Metabolic Process Glial Cell Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process MiRNA Processing Regulation Of Gene Expression MiRNA Binding Negative Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gliogenesis Regulation Of Glial Cell Proliferation Identical Protein Binding Pre-miRNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Nucleoplasm Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Receptor Tyrosine Kinase Binding Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Regulation Of MiRNA Processing Regulation Of Regulatory NcRNA Processing
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