LYAR and SDCBP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		LYAR	SDCBP2
Description		Ly1 antibody reactive	syndecan binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Nucleoplasm Nucleolus Cytoplasm Cell Projection	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Nuclear Speck Extracellular Exosome
	Molecular Function	DNA Binding RNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process RRNA Processing Innate Immune Response Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase I Erythrocyte Development Positive Regulation Of Phagocytosis	Nervous System Development Cell Population Proliferation Intracellular Signal Transduction Intracellular Transport
Pathways
Drugs
Diseases
GWAS		Disease progression in age-related macular degeneration ( 29346644)	Estimated glomerular filtration rate ( 31152163) Metabolite levels ( 23823483)
Interacting Genes		16 interacting genes: ADSS1 BEND7 CD2 FGF18 GSK3B OGT PDE4B PHF20L1 PRKRA SDCBP2 SNRPA SREK1IP1 TERF1 TERF2 ZBTB16 ZHX1	66 interacting genes: ADAP1 AKAP17A AP1M1 ARF4 BEND7 C1orf35 CHCHD1 CRCT1 CRY2 CT45A1 CT45A10 CT45A3 CT45A5 CTH DMC1 DPPA2 EIF1AD FAM133A FAM13C FAM9B FBXO28 GABRA3 HSBP1 LGALS14 LGALS2 LYAR MED4 NFASC NFU1 NKAPD1 NOP56 NPM2 NRXN1 NUF2 PAFAH1B3 PDCD6IP PHC1 PRM2 PRPF38A PRPF40A PRR13 PTMS RNF111 RNPS1 RPL22 RPL22L1 RPL41 SDCBP SEC23A SREK1IP1 SYT17 TCP11L1 TDO2 THAP6 TIFA TM4SF1 TNNT1 TNP1 TRAF1 VAX1 VPS25 YTHDC1 ZCCHC10 ZCCHC17 ZNF581 ZRSR2
Entrez ID		55646	27111
HPRD ID		10064	18032
Ensembl ID		ENSG00000145220	ENSG00000125775
Uniprot IDs		Q9NX58	Q9H190
PDB IDs		6ZMI 6ZMO 6ZVH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Shelterin Complex Telomerase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly NSL Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Telomere Capping Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Protein Catabolic Process RNA-templated DNA Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Telomeric DNA Binding Protein Homodimerization Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Cartilage Development Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Telomere Maintenance Identical Protein Binding Nucleoplasm Regulation Of Proteasomal Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Macromolecule Metabolic Process Male Germ Cell Nucleus Regulation Of Chondrocyte Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of Metabolic Process Superior Temporal Gyrus Development	Protein Binding
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