AMBRA1 and GABARAPL1

Number of citations of the paper that reports this interaction (PubMedID 30217973)
71

Data Source:
BioGRID (unspecified method)

		AMBRA1	GABARAPL1
Description		autophagy and beclin 1 regulator 1	GABA type A receptor associated protein like 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Autophagosome Endoplasmic Reticulum Cytosol Cytoskeleton Focal Adhesion Axoneme Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Anchoring Junction Cul4-RING E3 Ubiquitin Ligase Complex	Autophagosome Membrane Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ciliary Basal Body
	Molecular Function	Protein Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding GTPase Binding Protein Phosphatase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding Phospholipid Binding Phosphatidylethanolamine Binding Tat Protein Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding
	Biological Process	Autophagosome Assembly G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitophagy Regulation Of Transcription By RNA Polymerase II Autophagy Nervous System Development Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Autophagy Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Ubiquitination Neural Tube Development Cell Differentiation Response To Nutrient Levels Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Mitochondrial Depolarisation Positive Regulation Of Mitophagy Positive Regulation Of Free Ubiquitin Chain Polymerization Regulation Of G1/S Transition Of Mitotic Cell Cycle	Autophagosome Assembly Mitophagy Autophagy Cellular Response To Nitrogen Starvation Glycophagy Autophagosome Maturation
Pathways		Macroautophagy	Macroautophagy
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Immunoglobulin A ( 20694011) Insulin-related traits (multivariate analysis) ( 32002517) Normal facial asymmetry (angle of deformation score) ( 30631343) Schizophrenia ( 28991256 29483656 30285260) Selective IgA deficiency ( 27723758)
Interacting Genes		22 interacting genes: AKT1 ALX4 BECN1 CCND1 CHUK CREM GABARAP GABARAPL1 GABARAPL2 HSD17B12 KBTBD4 MAP1LC3A MAP1LC3B MAP1LC3C MTCH2 MTOR PEX11A RNF2 SLC35C1 SNCA UBC UBE2D3	87 interacting genes: AHNAK2 AMBRA1 ANK2 APPL1 ARFGAP1 ATG13 ATG4A ATG4B ATG4D AZI2 BICC1 BNIP3L BRD9 BSCL2 BSDC1 CALCOCO1 CALCOCO2 CARS2 CCT2 CDC37 CREB3L2 CUL3 DISC1 DVL2 DYNLL1 ERBB2 ERBB3 FUNDC1 G3BP1 KBTBD7 KRTAP10-3 KRTAP10-7 KRTAP10-9 KXD1 MAP4K2 MAPK15 MEFV MLX MYBPC1 NCOR1 NEDD4 NFIA NUFIP2 OPRK1 OPTN OSBPL3 PBXIP1 PSMB4 PTPRR RABGAP1 RABGAP1L RB1CC1 RCN2 RESF1 RETREG3 SCYL3 SEC62 SNCA SQSTM1 SRPK1 SRPK2 STK3 STRN3 TAX1BP1 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B THAP7 TMEM131 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 UMAD1 VDR WDFY3 ZBTB22
Entrez ID		55626	23710
HPRD ID		10975	07601
Ensembl ID		ENSG00000110497	ENSG00000139112
Uniprot IDs		A0A075B6T1 Q9C0C7	Q9H0R8
PDB IDs		8WQR	2L8J 2R2Q 5DPT 5LXH 5LXI 6HOI 6HOL 6YOO 7AA7 7AA9 7JHX 8X8A
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Assembly Autophagosome Maturation Autophagosome Organization Mitophagy Cellular Response To Starvation Response To Starvation Autophagy Of Mitochondrion Autophagosome Cellular Response To Nutrient Levels Macroautophagy Vacuole Organization Autophagosome Membrane Phospholipid Binding Response To Nutrient Levels Protein-containing Complex Disassembly Autophagy Ubiquitin Protein Ligase Binding Response To Iron(II) Ion Response To Iron Ion Cellular Response To Stress Beta-tubulin Binding Cellular Response To Amino Acid Starvation GABA Receptor Binding Response To Amino Acid Starvation Organelle Assembly Cellular Response To Copper Ion Cytoplasmic Vesicle Negative Regulation Of Catabolic Process Catabolic Process Negative Regulation Of Lysosome Organization Cellular Response To Oxygen-glucose Deprivation Negative Regulation Of Autophagy Response To Copper Ion Negative Regulation Of Macroautophagy Microtubule Binding Organelle Organization Endomembrane System Regulation Of Generation Of Precursor Metabolites And Energy Response To Stress Organelle Membrane Cellular Response To Decreased Oxygen Levels Response To Vitamin E Generation Of Precursor Metabolites And Energy Cellular Response To Oxygen Levels Response To Metal Ion Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Mitochondrial ATP Synthesis Coupled Electron Transport Microtubule	Autophagosome Regulation Of Cilium Assembly Autophagy Macroautophagy GTPase Activator Activity Regulation Of Organelle Assembly Cytosol Regulation Of Autophagy Positive Regulation Of Autophagy Autophagy Of Mitochondrion Regulation Of Cell Projection Assembly Mitophagy Autophagosome Assembly Autophagosome Organization Aggrephagy Cytoplasmic Vesicle Piecemeal Microautophagy Of The Nucleus Cytoplasm Regulation Of Cell Projection Organization Microautophagy Nucleophagy Positive Regulation Of Catabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Vacuole Organization Regulation Of Organelle Organization Positive Regulation Of Metabolic Process Protein-phosphatidylethanolamide Deconjugating Activity Catabolic Process Protein Delipidation Response To Mitochondrial Depolarisation Organelle Assembly Regulation Of Macroautophagy Atg1/ULK1 Kinase Complex Regulation Of Cellular Component Organization Positive Regulation Of Macroautophagy Regulation Of Intracellular Signal Transduction Protein Polyubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Phagophore Assembly Site Negative Regulation Of Signal Transduction ERBB3:ERBB2 Complex Protein Localization To Phagocytic Vesicle Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Metabolic Process Response To Stress Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Viral Process
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